中文摘要：黄曲霉毒素，玉米和花生中普遍存在的一种霉菌毒素，暴露后会引起撒哈拉以南非洲地区儿童发育迟缓。初步研究结果显示，尼泊尔巴德冈儿童遭受着慢性黄曲霉毒素暴露，几何平均值为AFB1-赖氨酸3.62pg/mg白蛋白，暴露幅度与非洲相当，那里已经注意到黄曲霉毒素生物标志物关系着儿童生长发育不良。下一步研究将分析黄曲霉毒素水平、生长与MAL-ED研究收集的其它风险因子的关系。
外文摘要：Exposure to aflatoxin, a mycotoxin common in maize and groundnuts, has been associated with childhood stunting in sub-Saharan Africa. In an effort to further our understanding of growth impairment in relation to mycotoxins and other risk factors, biospecimens from a cohort of children enrolled in the Bhaktapur, Nepal MAL-ED study were assessed for aflatoxin exposure at 15, 24, and 36 months of age. Exposure was assessed through a well-established serum biomarker, the AFB1-lysine adduct. In this manuscript, the levels of aflatoxin exposure in the Nepal cohort were compared with those observed in aflatoxin studies, with child growth parameters as a health outcome. Results from this preliminary analysis demonstrated chronic aflatoxin exposure in children residing in Bhaktapur with a geometric mean of 3.62 pg AFB1-lysine/mg albumin. The range of exposure in this population is similar to those in African populations where associations with aflatoxin biomarkers and poor child growth have been observed. Future work will analyze the relationships between aflatoxin levels, growth, and other risk factors collected by the MAL-ED study.
外文关键词：aflatoxin, child growth；Nepal；preliminary exposure
作者：Mitchell, NJ；Riley, RT；Egner, PA；Groopman, JD；Wu, F
作者单位：Michigan State Univ
期刊名称：JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
期刊影响因子：3.141
出版年份：2017
出版刊次：1
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