中文摘要：本研究旨在弄清低剂量ZEN暴露的过程是否能改变血清血液生化指标。结果发现，低剂量ZEN暴露比高剂量造成的代谢变化更大。在暴露初始阶段观察到霉菌毒素具有刺激作用，但在触发了补偿反应和适应机制后消除，由于能量过多损耗，这可能意味着更加有效的饲料利用和/或解毒过程。在毒素暴露的六周中实验组的体重增加值有四周一致居高。以上变化伴有葡萄糖浓度降低和更高的总蛋白含量（增长趋势），这可能影响了体重增加率。
外文摘要：The aim of the study was to examine whether the process of exposure to low doses of ZEN generates changes in the hematological and biochemical image of blood serum. During the experiment, pre-pubertal gilts (up to 25 kg) were administered per os with ZEN at a dose of 40 μg/kg BW (group E, n = 18) or placebo (group C, n = 21) on a daily basis for 42 days. Blood samples for investigation were collected seven times at intervals of one week. In the experimental groups, slight but statistically significant changes in the values of selected biochemical blood indices such as glucose, ALT, Pin., total protein and Fe, or in hematological indices such as RBC, MCV, PLT, WBC, basophils, eosinophiles and monocytes were observed. Based on statistical analysis between the groups, differences in the values of WBC, basophiles, peroxidase negative cells, Hb, Ht, MCV, HDW, glucose, ALT, AP, total protein, iron or potassium were found. In Group E, decreasing trends in the values of PLT and glucose, and increasing trends in the values of total protein, Pin., Na and Cl were found. The described situations occurred during the last three weeks of exposure. Low levels of exposure to ZEN lead to completely different changes in the metabolic profile than those resulting from higher doses of the toxin. The stimulatory effect of mycotoxins, observed in initial stages of exposure, is eliminated when the compensatory response and adaptive mechanisms are triggered, and due to excessive loss of energy, which may point to more efficient feed utilization and/or detoxification processes. The values of body weight gain obtained in Group E were monotonically higher in four out of the six investigated weeks of exposure. The above changes were accompanied by a decrease in glucose concentrations and higher total protein levels (a rising tendency), which could have affected the rate of body weight gain.
外文关键词：Zearalenone in low doses；Blood biochemical indices；Hematological indices；Body weight；Pre-pubertal gilts
作者：Gajecka, M；Tarasiuk, M；Zielonka, L；Dabrowski, M；Gajecki, M
作者单位：Univ Warmia & Mazury
期刊名称：RESEARCH IN VETERINARY SCIENCE
期刊影响因子：1.504
出版年份：2016
出版刊次：12
点击下载：评估青春期前母猪长期受单一低剂量玉米赤霉烯酮(ZEN)暴露引起的代谢和体重变化的风险