中文摘要： 小分子泛素样修饰体（SUMOs）在SUMOylation过程中能可逆的附属于靶蛋白，这个过程对几个重要的真核细胞活动具有影响。然而很少有关于黄曲霉SUMO和SUMOylation的认识。本研究中，我们发现了一种关于黄曲霉的新SUMO（AFSUMO），并且验证了这种致病性丝状真菌SUMOylation的方式。研究结果不仅揭示了黄曲霉真菌毒力和毒素特性的潜在机理，而且提供了一种有望控制这种病原真菌的新方法和新策略。
外文摘要：Small ubiquitin-like modifiers (SUMOs) can be reversibly attached to target proteins in a process known as SUMOylation, and this process influences several important eukaryotic cell events. However, little is known regarding SUMO or SUMOylation in Aspergillus flavus. Here, we identified a novel member of the SUMO family in A. flavus, AfSumO, and validated the existence of SUMOylation in this pathogenic filamentous fungus. We investigated the roles of AfsumO in A. flavus by determining the effects of AfsumO mutations on the growth phenotype, stress response, conidia and sclerotia production, aflatoxin biosynthesis, and pathogenicity to seeds, and we found that SUMOylation plays a role in fungal virulence and toxin attributes. Taken together, these results not only reveal potential mechanisms of fungal virulence and toxin attributes in A. flavus, but they also provide a novel approach for promising new control strategies of this fungal pathogen.
外文关键词：AfsumO; Aspergillus flavus; SUMOylation; aflatoxin; morphogenesis; pathogenicity
作者：XY Nie；S Yu；M Qiu；等
作者单位：福建农林大学
期刊名称：journal of agricultural and food chemistry
期刊影响因子：2.857
出版年份：2016
出版刊次：9
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