中文摘要：由镰刀菌属真菌产生的玉米赤霉烯酮（ZEA）和脱氧雪腐镰刀菌烯醇（DON）是近来常见的真菌毒素。它们是影响人类和动物健康以及畜牧业生产力的重要因素。本研究旨在低剂量的ZEA和DON对猪十二指肠组织结构的影响。结果表明，低剂量的镰刀菌毒素膳食暴露可能是小肠亚临床验证的重要危险因素。
外文摘要：Deoxynivalenol (DON) and zearalenone (ZEN), produced by microfungi of theFusariumfamily, are among the most commonly occurring mycotoxins. They are considered important factors affecting human and animal health as well as livestock productivity. The aim of this study was to determine the effect of low doses of these mycotoxins on the histological structure of the pig duodenum. The study was performed on 72 gilts, with initial weights of approximately 25kg, divided into 4 equal groups. Group I receivedper osZEN (40μg/kg BW), group II—DON (12μg/kg BW), group III—ZEN (40μg/kg BW) and DON (12μg/kg BW), and group IV—vehicle. The pigs were killed after 1, 2, 3, 4, 5 and 6 weeks of the treatment, and the duodenum samples were prepared for histological investigations. The slides were digitalized and subjected to morphometrical analysis. The treatment with DON and ZEN did not change the architecture of the mucosa or the ratio between goblet and adsorptive cells in the epithelium. The administration of DON induced an increase in the number of lymphocytes in the mucosal epithelium. Both mycotoxins, administered alone or together, increased the quantity of lymphocytes, plasma cells and macrophages with black-brown granules in the lamina propria. The time-courses of changes in the number of defense system cells evoked by DON and ZEN were different. In conclusion, dietary exposure to low doses ofFusariummycotoxins should be considered an important risk factor for subclinical inflammation in the small intestine.
外文关键词：Deoxynivalenol；Zearalenone；Pig；Intestine；Histology
作者：Lewczuk, B；Przybylska-Gornowicz, B；Gajecka, M；等
作者单位：Univ Warmia & Mazury
期刊名称：EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
期刊影响因子：1.716
出版年份：2016
出版刊次：2-3
点击下载：低量吸收饲料中玉米赤霉烯酮和脱氧雪腐镰刀菌烯醇对母猪十二指肠组织结构的影响