中文摘要：许多表达抗虫蛋白的转基因作物已经过广泛的测试证明与其对应的非转基因品种具有相同的安全性，从而被商业化。本文通过对大鼠亚慢性口服毒性的测试，来研究新研发的表达cry2A*基因的抗虫转基因水稻的安全性。作者将转基因水稻和非转基因水稻分别纳入大鼠饮食中，且基于日常临床体征、检查体重、食物消耗量、血液学、血液生化、脏器重量或大体和组织病理学检查，没有发现与治疗相关的不良反应或毒性反应。研究结果表明，表达cry2A*基因的转基因水稻与非转基因水稻作为粮食的安全性是一样的。
外文摘要：Numerous genetically modified (GM) crops expressing proteins for insect resistance have been commercialized following extensive testing demonstrating that the foods obtained from them are as safe as that obtained from their corresponding nonGM varieties. In this paper, we report the outcome of safety studies conducted on a newly developed insectresistant GM rice expressing the cry2A* gene by a subchronic oral toxicity study on rats. GM rice and non-GM rice were incorporated into the diet at levels of 30, 50, and 70 % (w/w), No treatment-related adverse or toxic effects were observed based on an examination of the daily clinical signs, body weight, food consumption, hematology, serum biochemistry, and organ weight or based on gross and histopathological examination. These results demonstrate that the GM rice with cry2A* gene is as safe for food as conventional non-GM rice.
外文关键词：Genetically modified rice；Cry2A*gene; Safety assessment；90-Day feeding study
作者：Shiying Zou；Kunlun Huang；Wentao Xu；Yunbo Luo；Xiaoyun He
作者单位：中国农业大学
期刊名称：TRANSGENIC RESEARCH
期刊影响因子：2.054
出版年份：2016
出版刊次：4
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