中文摘要：GRACE是转基因生物风险评估及沟通的依据，www.project是由欧洲委员会第七框架计划项目资助的。GRACE的关键目标是通过90天的饲养试验进行动物研究及扩展的时间框架分析，且进行转基因玉米的体外研究和模拟研究来比较评估体外研究和模拟研究在转基因植物风险评估中的应用。本文分别用转基因玉米MON81、其近等基因非转基因玉米和其他常规玉米对Wistar Han RCC大鼠进行了一年的饲养试验。另外，在饲养试验中参照了2011年EFSA科学委员会发表的研究指南和OECD测试指南452。研究结果表明，进过慢性暴露后，含有高达33%转基因玉米MON810的饮食不会对雄性和雌性Wistar Han RCC大鼠产生不利影响。
外文摘要：The GRACE (GMO Risk Assessment and Communication of Evidence; www.project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure.
外文关键词：Food/Feed Guidance Document of the EFSA Scientific Committee (2011)；Genetically modified maize MON810；GRACE；OECD Test Guideline No. 452-Chronic toxicity studies (2009)；Rat feeding trial；Chronic oral toxicity study
作者：Zeljenkova, Dagmar；Alacova, Radka；Ondrejkova, Julia；Ambrusova, Katarina等
作者单位：Univ Vet Med Hannover
期刊名称：ARCHIVES OF TOXICOLOGY
期刊影响因子：6.637
出版年份：2016
出版刊次：10
点击下载：转基因玉米MON810饲喂Wistar Han RCC大鼠的一年口服毒性研究（欧盟第七框架计划项目GRACE）