中文摘要：黄曲霉毒素M1（AFM1）是一种重要的生物标志物，可用于评估人类和动物的黄曲霉毒素暴露。本研究旨在通过巴西母乳和婴儿奶粉的消费情况评估该地区婴儿对黄曲霉毒素的暴露程度。为了达到这一研究目标，作者从巴西南部收集了94个母乳（BM）样品，并从巴西正常商业化的婴儿奶粉（IPM）中收集了16个样品，通过分析样品中的SFM1水平来从计算婴儿的每日摄入量（EDI）。研究结果表明，婴儿AFM1暴露很低，但是持续的黄曲霉毒素水平监测对于尽可能减少婴儿健康风险而言至关重要。
外文摘要：Aflatoxin M1 (AFM1) is an important biomarker that can be used to evaluate aflatoxin exposure in both humans and animals. The aim of this study was to evaluate the exposure degree of infants to AFM1 through consumption of breast milk and infant powdered milk in Brazil. For this purpose, the estimated daily intake (EDI) for infants was calculated based on the AFM1 levels analyzed in 94 breast milk (BM) samples collected in Southern Brazil, and 16 infant powdered milk (IPM) samples commonly commercialized in Brazil. AFM1 was detected in 5.3% (n = 5) and 43.8% (n = 7) of BM and IPM samples, with mean levels of 0.003 ng/g and 0.011 ng/g, respectively. All the IPM samples showed AFM1 levels lower than those established by the Brazilian guidelines (5 ng/g), and in most of the samples (81.25%) levels were below the maximum limit tolerated by the European Commission (0.025 ng/g). The EDI of AFM1 for infants aged zero to 12 months old showed values from 0.018 to 0.069 ng/kg body weight/day for BM, and 0.078 to 0.306 ng/kg body weight/day for IPM. Hazard index (HI) values for BM and IPM were less than one, except for IPM intended for infants up to one month. In conclusion, the exposure of infants to AFM1 was low, but continuous monitoring of mycotoxin levels is essential to minimize infant health risk.
外文关键词：exposure；mycotoxin；milk；infant；safety；carry-over
作者：Ishikawa, AT; Takabayashi-Yamashita, CR; Ono, EYS; Bagatin, AK; Rigobello, FF; Kawamura, O; Hirooka, EY; Itano, EN
作者单位：Univ Estadual Londrina,Brazil.
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2016
出版刊次：9
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