中文摘要：本文旨在研究黄曲霉毒素B1 (AFB₁)的毒性效应，并评估破壁灵芝孢子(SSGL)对减轻肉鸡黄曲霉毒素中毒的作用。结果显示，整个实验过程中，日粮受低水平AFB1污染显著降低了肉鸡的平均日采食量(p < 0.05)和平均日增重(p < 0.05)；血清总蛋白、IgA和IgG的含量均显著下降。此外，日粮受低水平AFB1污染不仅能显著升高肉鸡肝脏及脾脏中过氧化氢和脂质过氧化水平(p < 0.05)，而且能显著降低总抗氧化能力及过氧化氢酶、谷胱甘肽过氧化物酶、羟自由基清除剂的活性(p < 0.05)；另外，受AFB₁污染的日粮中掺入了SSGL后能抵消这种负作用，表明SSGL对黄曲霉毒素中毒有保护作用。
外文摘要：This study was conducted to investigate the toxic effects of aflatoxin B₁ (AFB₁) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were randomly divided into four dietary treatments; the treatment diets were: Control (a basal diet containing normal peanut meal); AFB₁ (the basal diet containing AFB₁-contaminated peanut meal); SSGL (basal diet with 200 mg/kg of SSGL); AFB₁+SSGL (supplementation of 200 mg/kg of SSGL in AFB₁ diet). The contents of AFB₁ in AFB₁ and AFB₁+SSGL diets were 25.0 μg/kg in the starter period and 22.5 μg/kg in the finisher period. The results showed that diet contaminated with a low level of AFB₁ significantly decreased (p < 0.05) the average daily feed intake and average daily gain during the entire experiment and reduced (p < 0.05) serum contents of total protein IgA and IgG. Furthermore, a dietary low level of AFB₁ not only increased (p < 0.05) levels of hydrogen peroxide and lipid peroxidation, but also decreased (p < 0.05) total antioxidant capability, catalase, glutathione peroxidase, and hydroxyl radical scavenger activity in the liver and spleen of broilers. Moreover, the addition of SSGL to AFB₁-contaminated diet counteracted these negative effects, indicating that SSGL has a protective effect against aflatoxicosis.
外文关键词：spores of Ganoderma lucidum； oxidative stress； aflatoxins； antioxidant capability
作者：Liu, T； Ma, QG； Zhao, LH； Jia, R； Zhang, JY； Ji, C； Wang, XY
作者单位：China Agr Univ
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2016
出版刊次：10
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