中文摘要：本研究通过196天对五指山小型猪的饲喂试验，来探讨表达Cry1Ac基因的转基因玉米对其生长性能、免疫反应和健康状况的慢性作用。作者在三个生长阶段根据性别和体重将72只五指山小型猪随机分成两组，分别对其饲喂含65%非转基因玉米和转Cry1Ac基因玉米的饲料。并对转基因玉米对猪的潜在毒性效应进行了探讨。研究发现，在任何生长阶段两组猪的生长性能和血液学参数没有差异；虽然两组猪的丙氨酸氨基转移酶的血清含量、相对肾重、某些免疫反应有细微差异，但这些不是饮食差异导致的。研究结果表明，用携带cry1Ac基因的Bt玉米长期饲喂五指山小型猪，对其各个生长阶段的生长、免疫反应和健康状况指标没有不利影响。
外文摘要：BACKGROUND：The objective of the present study was to investigate the chronic effect of transgenic maize lines by the insertion of the cry1Ac gene from Bacillus thuringiensis (Bt) on the growth performance, immune response and health using a Wuzhishan miniature pig model through a 196-day feeding study.
RESULTS：Based on the gender and weight, 72 Wuzhishan miniature pigs were randomly assigned one of the diets containing 65% non-transgenic isogenic corn or Bt corn at three stages of growth (day 0-69, 70-134 and 135-196). The potential toxicological effects of transgenic corn on pigs were explored. No difference between the diet treatments for growth performance and haematology parameters at any stages of growth. Although subtle differences in serum content of alanine aminotransferase, relative kidney weight and some immune response were observed between the Bt group and isogenic group, they were not considered as diet treatment-related.
CONCLUSION：Long-term feeding Bt corn carrying cry1Ac genes to Wuzhishan miniature pigs did not indicate adverse effects on the growth, immune response and health indicators at any stages of growth.
外文关键词：corn；cry1Ac；safety；transgenic crop； miniature pig
作者：Chen, Liang；Sun, Zhe；Liu, Quanwei；等.
作者单位：中国农业科学院
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
期刊影响因子：2.076
出版年份：2016
出版刊次：9
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