中文摘要：本文通过90天的喂养试验，来调查含有组织β防御素-3的转基因牛奶对小鼠的影响。调查的参数包括对转基因牛奶的消化率、一般体格检查、胃排空功能、肠道通透性、小鼠肠道菌群组成、基因水平转移的可能性（HGT）。调查的重点是胃肠道，这是因为胃肠道是第一个与食物接触的场所，而且其在宿主体内的代谢反应、营养吸收和免疫调节中起着至关重要的作用。而传统的分析转基因产品潜在毒性风险的方法很少关注胃肠道健康问题。本文研究结果表明，转基因牛奶在人工胃液中是容易被消化的；且与传统的牛奶相比，它没有对整体健康和胃肠道健康造成不利影响；基因水平转移的可能性不大。本文的研究可能丰富了转基因产品对胃肠道健康的安全性研究。
外文摘要：This study was performed to investigate the effects of genetically modified (GM) milk containing human beta-defensin-3 (HBD3) on mice by a 90-day feeding study. The examined parameters included the digestibility of GM milk, general physical examination, gastric emptying function, intestinal permeability, intestinal microflora composition of mice, and the possibility of horizontal gene transfer (HGT). The emphasis was placed on the effects on gastrointestinal (GI) tract due to the fact that GI tract was the first site contacting with food and played crucial roles in metabolic reactions, nutrition absorption and immunity regulation in the host. However, the traditional methods for analyzing the potential toxicological risk of GM product pay little attention on GI health. In this study, the results showed GM milk was easy to be digested in simulated gastric fluid, and it did not have adverse effects on general and GI health compared to conventional milk. And there is little possibility of HGT. This study may enrich the safety assessment of GM product on GI health.
作者：Chen, Xin; Yang, Yange; Shi, Zhaopeng; 等
作者单位：Northwest A&F Univ
期刊名称：PLOS ONE
期刊影响因子：3.057
出版年份：2016
出版刊次：7
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