外文摘要：NOVELTY - Template composition comprises: an aflatoxin template (I) having a molecular structure that mimics the structure, size, shape and/or other chemical characteristics of at least one natural aflatoxin; monomers that are chemically-bondable to each other; and a carrier.
USE - The template composition is useful: for forming a complex of a crosslinked polymer and a molecularly imprinted polymer (all claimed), which is useful to detect presence of aflatoxins for traceability purposes and to remove aflatoxins from a contaminated source or materials containing aflatoxin e.g. beverage, a foodstuff, an animal feed and a nutraceutical composition; and in dietary, therapeutic, prophylactic, food and beverage processing and manufacture and liquid filtering.
ADVANTAGE - The template composition: provides the molecularly imprinted polymer, which is safe, reusable, and economically realizable/producible, and exhibits high water sorption and retention of aflatoxins, high affinity and selectivity for aflatoxin containing compounds, high enantioselectivity, low substrate selectivity, and vivo stability and solubility; and reduces or eliminates the need to handle large quantities of toxic aflatoxins and to prevent bleeding of aflatoxins out of the polymer.
DETAILED DESCRIPTION - Template composition comprises: an aflatoxin template of formula (I) having a molecular structure that mimics the structure, size, shape and/or other chemical characteristics of at least one natural aflatoxin; monomers that are chemically-bondable to each other; and a carrier.
R3 = H, 1-6C alkoxy, or substituted 1-6C alkyl; either
R1 = 1-6C alkyl (optionally substituted), H or halo substituted 1-6C alkyl; and
R2 = 1-6C alkyl (optionally substituted), halo, halo substituted 1-6C alkyl, CH2C(O)OR1a or CH(C(O)OR1a)2; or
R1+R2 = 4-7C cycloalkyl ring, halo substituted 4-7C cycloalkyl ring, oxo substituted 4-7C cycloalkyl ring, 4-7C cycloalkoxy ring, hydroxy substituted 4-7C cycloalkyl ring or carboxylic group substituted 4-7C cycloalkyl; and
R1a = 1-6C alkyl (optionally substituted) or H.
INDEPENDENT CLAIMS are also included for:
(1) a complex of a crosslinked polymer made from monomers that are chemically bonded to each other and the aflatoxin template (I), where the aflatoxin template is removable from the crosslinked polymer to form a cavity sized and/or shaped to allow an aflatoxin to be boundable in it; and
(2) a molecularly imprinted polymer comprising a crosslinked polymer made from monomers that are chemically bonded to each other, where the crosslinked polymer defines many cavities, at least one of the cavities is made using aflatoxin template (I), and the cavity is sized and/or shaped to allow an aflatoxin to be boundable in it.
申请号：US2016347923-A1
专利号：US2016347923-A1
公开/公告号：US613562 ；US235283
申请/专利权人：ALLTECH INC (ALLT-N)
发明/设计人：YIANNIKOURIS, A；YERRAMREDDY, T R；MARTINEZ, J J；WITHERS, J R
分类号：B01J-020/26；C08F-222/10；C08J-009/26
点击下载：黄曲霉毒素模板用于形成分子印迹聚合物，去除污染源中的黄曲霉毒素，包含具有模拟天然黄曲霉毒素大小的分子结构、单体和载体。