中文摘要：研究将埃博拉病毒与PLGA-PLL/γ-PGA纳米颗粒进行混合组成复合物，并采用微针贴片技术进行皮肤免疫。与单独使用疫苗免疫相比，该纳米颗粒传递系统构建的复合物提高了疫苗的热稳定性和免疫原性；与肌肉免疫相比，免疫贴片免疫能够激发更强的免疫反应。
 
外文摘要：Ebola DNA vaccine is incorporated into PLGA-PLL/gamma PGA nanoparticles and administered to skin using a microneedle (MN) patch. The nanoparticle delivery system increases vaccine thermostability and immunogenicity compared to free vaccine. Vaccination by MN patch produces stronger immune responses than intramuscular administration.
外文关键词：NONHUMAN-PRIMATES; INFLUENZA VACCINE; MARBURG VIRUS; DRUG-DELIVERY; HEPATITIS-C; SKIN; IMMUNIZATION; PROTECTION; VECTORS; ELECTROPORATION
作者：Yang, HW; Ye, L; Guo, XD; Yang, CL; Compans, RW; Prausnitz, MR
作者单位：美国佐治亚理工学院
期刊名称：ADVANCED HEALTHCARE MATERIALS
期刊影响因子：5.76
出版年份：2017
出版刊次：1
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