中文摘要：研究分析了氟化脂体外与多肽抗原结合对体液免疫的促进作用。利用抗A组链球菌的多肽疫苗检测了氟化脂对体液免疫的影响。结果表明，包含氟化脂的疫苗与使用CFA的疫苗相比，小鼠的抗体滴度没有明显变化，但其抗体滴度高于含无氟血脂的疫苗。
外文摘要：Safe immunostimulants (adjuvants) are essential for the development of highly potent peptide-based vaccines. This study examined for the first time whether fluorinated lipids could stimulate humoral immunity in vivo when conjugated to peptide antigen. The impact of fluorination on humoral immunity was tested using a library of peptide-based vaccine candidates against the group A streptococcus (GAS). The fluorinated constructs stimulated similar mouse IgG titers to those elicited by complete Freund's adjuvant (CFA) and were higher than those produced in mice that received the nonfluorinated constructs.
外文关键词： Fluorinated lipid；self-adjuvant；cellular immunity；humoral immunity；peptide-based vaccine；nanoparticle
作者：Hussein, WM; Mukaida, S; Azmi, F; Bartlett, S; Olivier, C; Batzloff, MR; Good, MF; Slovarczynski, M; Toth, I
作者单位：澳大利亚昆士兰大学
期刊名称：ACS MEDICINAL CHEMISTRY LETTERS
期刊影响因子：3.355
出版年份：2017
出版刊次：2
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