中文摘要：本研究旨在评估一种新型抗肺炎支原体和圆环病毒的疫苗在母源免疫猪圆环病毒疫苗后的效率。结果表明：应用新疫苗免疫后能极显著降低屠宰时肺部病变程度，平均肺损害评分值显著低于对照组；免疫后的猪只圆环病毒2病毒血症发生率显著下降，日增重显著增加。
外文摘要：Mycoplasma hyopneumoniae (M. hyo) and Porcine Circovirus Type 2 (PCV2) are major pathogens that cause significant health problems in swine worldwide. Maternal derived immunity (MDI) has been suggested as a significant immediate defence factor for newborn piglets and may interfere with piglet's vaccination-induced immunity. The study aimed to assess the efficacy of a novel combination vaccine (consisting of PCV2 subunits and inactivated M. hyo strain J), against PCV2 and M. hyo natural infection [Porcilis (R) PCV M Hyo (MSD Animal Health, Boxmeer, the Netherlands)], in the presence of strong maternally derived PCV2 immunity (antibody titre averaged 11.08 log(2)), under field conditions. The study was performed according to a controlled, randomized and blinded design in a Greek swine unit with Enzootic Pneumonia (EP) and subclinical PCV2 infection. In total, 600 healthy three-week-old suckling piglets were allocated randomly, either to treatment (vaccinated with the test product) or control group (injected with sterile buffered saline). Results: Vaccination significantly reduced the severity of lung lesions at slaughter (lesions of cranio-ventral pulmonary consolidation) (P < 0.001). The overall mean lung lesion score (LLS) was 9.6 in the vaccinated group and 12.2 in controls. The level of PCV2 viraemia was significantly reduced in vaccinated pigs. Furthermore, 25 g higher average daily weight gain (ADWG) was observed during the finishing phase (P < 0.001) and 18 g greater ADWG overall (P < 0.001). Conclusions: Results of LLS, PCV2 viremia and ADWG support the test product's efficacy in the face of strong maternally derived PCV2 immunity.
外文关键词： Porcilis PCV M Hyo; Enzootic pneumonia; Mycoplasma hyopneumoniae; Porcine circovirus type 2; Pigs
作者： Tassis, Panagiotis D.; Tsakmakidis, Ioannis; Papatsiros, Vassileios G.; Koulialis, Dimitrios; Nell, Tom; Brellou, Georgia; Tzika, Eleni D.
作者单位：塞萨洛尼基亚里士多德大学
期刊名称：BMC VETERINARY RESEARCH
期刊影响因子：1.643
出版年份：2017
出版刊次：4
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