中文摘要：研究分析了应用内皮细胞选择素诊断肺炎支原体肺炎感染儿童心肌损伤方面的作用。结果表明，在138名肺炎支原体肺炎感染儿童中，有40名病人出现心肌损伤，另外98名病人未出现心肌损伤；心肌损伤病人血清内皮细胞选择素的浓度为40.22 +/- 4.80 ng/mL，未出现心肌损伤的病人血清内皮细胞选择素的浓度为18.55 +/- 2.16 ng/mL，而健康对照组血清内皮细胞选择素的浓度为12.39 +/- 3.27 ng/mL。具有心肌损伤的40名病人血清内皮细胞选择素浓度的受试者工作特征曲线值下面积为0.945 (95% CI: 0.899-0.991)，最优诊断切值为29.93 ng/mL（阳性似然比=72.5）.该研究表明：内皮细胞选择素是判断肺炎支原体肺炎感染病人心肌损伤的有效指标。
外文摘要：Backgrounds: Effects of myocardial injury on E-selectin remain unclear. Thus, we investigated the diagnostic value of E-selectin for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia. Methods: In this prospective and blinded clinical study, plasma E-selectin, cardiac troponin I, creatine kinase isoenzyme MB, interleukin-6 and tumor necrosis factor alpha concentrations were measured in paediatric patients with mycoplasma pneumoniae pneumonia (MPP group, n = 138). The control group comprised 120 healthy children. The definition of cardiac injury was based on cardiac troponin I or CK-MB (with or possibly without abnormal electrocardiogram evidence). Diagnostic value of E-selectin for myocardial injury was determined by analysing receiver operating characteristic curves. Results: Among the 138 mycoplasma pneumoniae pneumonia patients, 40 patients were identified with myocardial injury, while 98 patients were identified without myocardial injury. Plasma E-selectin concentrations were: 40.22 +/- 4.80 ng/mL, in patients with myocardial injury; 18.55 +/- 2.16 ng/mL, in patients without myocardial injury and 12.39 +/- 3.27 ng/mL, in healthy children. For the 40 patients identified with myocardial injury, area under the receiver operating characteristic curve value for plasma E-selectin concentrations was 0.945 (95% CI: 0.899-0.991), and optimal diagnostic cut-off value was 29.93 ng/mL (positive likelihood ratio = 72.5). Conclusion: E-selectin was shown to be an effective index for myocardial injury in paediatric patients with mycoplasma pneumoniae pneumonia, and its role in other causes of myocardial injury warrants further investigation.
外文关键词：E-selectin; diagnostic value; myocardial injury; mycoplasma pneumoniae pneumonia; children
作者：Deng, MH; Lin, CW; Sun, YN; Zeng, XL; Wen, F
作者单位：暨南大学
期刊名称：ANNALS OF CLINICAL BIOCHEMISTRY
期刊影响因子：2.119
出版年份：2017
出版刊次：1
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