中文摘要：本研究比较了印度人群中A型（H1N1）pdm09流感和季节性H3感染后细胞因子浓度的变化情况。结果表明：与季节性H3流感病毒相比，A型（H1N1）pdm09流感病毒更能激发机体激烈的细胞因子和趋化因子的反应。本研究表明，趋化因子可以作为疾病爆发和恶化的预警指标。针对宿主免疫反应调控的进一步研究将有助于流感的治疗与预警。
 
外文摘要：In India; the case fatality ratio of the pandemic A (H1N1) pdm09 influenza was relatively higher when compared to seasonal Influenza A infection. Hypercytokinemia or "cytokine storm" has been previously implicated in the pathogenesis of other influenza viruses. The present study was undertaken to compare the cytokine profiles of A(H1N1) pdm09 influenza and seasonal H3 infection in Indian population and to correlate the findings with disease severity. Plasma levels of 18 cytokines/chemokines were measured by flow-cytometry using a bead based assay in patients infected with A (H1N1) pdm09 virus (n = 96) and Influenza A seasonal H3 virus (n = 30) categorised into mild; moderate; and severe groups along with healthy controls (n = 36). There was an overall trend indicating an exuberant cytokine/chemokine response in A (H1N1) pdm09 as compared to seasonal H3 influenza; which was more evident in severe cases; suggesting a role for these cytokines/chemokines in the pathogenesis of A(H1N1) pdm09. Increased levels of CXCL-8/IL-8; IL-10; IL-6; and IL-17A were seen in both A(H1N1) pdm09 influenza and seasonal H3 cases when compared to healthy controls. However; dysregulated production of proinflammatory chemokines was seen more pronounced in A (H1N1) pdm09 influenza cases as compared to seasonal H3 cases. This study has brought forth the potential role of chemokines as prognostic indicators of disease severity and outcome. Further research on modulating the host immune response to limit severity of the disease could help in the treatment and management of influenza.
外文关键词：cytokines/chemokines; immunopathology; influenza virus
作者：Thomas, M; Mani, RS; Philip, M; Adhikary, R; Joshi, S; Revadi, SS; Buggi, S; Desai, A; Vasanthapuram, R
作者单位：印度国家精神健康和神经科学研究所
期刊名称：JOURNAL OF MEDICAL VIROLOGY
期刊影响因子：1.935
出版年份：2017
出版刊次：8
点击下载：促炎性趋化因子是流感A（H1N1）pdm09病毒感染导致的免疫反应的主要调节因子