中文摘要：本文对粘膜相关免疫反应的诱导过程进行了简单回顾，这些过程包括抗原摄取和树突状细胞亚群相关的抗原呈现。文章同时重点从近年来的报道中分析了一些粘膜疫苗佐剂的发展，重点分析了这些粘膜佐剂的作用方式。
 
外文摘要： Vaccine adjuvants induce innate immune responses and the addition of adjuvants to the vaccine helps to induce protective immunity in the host. Vaccines utilizing live attenuated or killed whole pathogens usually contain endogenous adjuvants, such as bacterial cell wall products and their genomic nucleic acids, which act as pathogen-associated molecular patterns and are sufficient to induce adaptive immune responses. However, purified protein-or antigen-based vaccines, including component or recombinant vaccines, usually lose these endogenous innate immune stimulators, so the addition of an exogenous adjuvant is essential for the success of these vaccine types. Although this adjuvant requirement is mostly the same for parental and mucosal vaccines, the development of mucosal vaccine adjuvants requires the specialized consideration of adapting the adjuvants to characteristic mucosal conditions. This review provides a brief overview of mucosa-associated immune response induction processes, such as antigen uptake and dendritic cell subset-dependent antigen presentation. It also highlights several mucosal vaccine adjuvants from recent reports, particularly focusing on their modes of action.
外文关键词：CD103(+) DENDRITIC CELLS; ATTENUATED INFLUENZA VACCINE; TOLL-LIKE RECEPTORS; INTESTINAL EPITHELIUM; ANTIBODY-RESPONSES; BACTERIAL-ANTIGENS; BELLS-PALSY; T-CELLS; IN-VIVO; INTRANASAL
作者：Aoshi, T
作者单位：日本大阪大学
期刊名称：VIRAL IMMUNOLOGY
期刊影响因子：1.432
出版年份：2017
出版刊次：8
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