中文摘要：许多材料可以用作免疫佐剂提高亚单位疫苗的免疫原性。在这些材料中，基于肽的水凝胶正逐渐引起研究者的注意，因为这些水凝胶能够应用于药物传递、癌症细胞抑制、疫苗佐剂及重要分析物的检测等领域。本研究介绍了利用一种新型的吲哚芳香家族构建短肽超分子水凝胶Indol-GFFY 和Indol-G(D)F(D)F(D)Y的方法，并分析了这些超分子水凝胶在疫苗佐剂制备方面的应用。
 
外文摘要：Many materials as immune adjuvant are researched to help raise immnogenicity of subunit vaccines. Among them, peptide-based hydrogels are gradually coming into notice because of their application in drugs delivery, cancer cell inhibition, vaccine adjuvants and detection of important analytes. In this work, we introduced a novel aromatic capping group based on indole to construct short peptide-based supramolecular hydrogelators Indol-GFFY and Indol-G(D)F(D)F(D)Y and demonstrated their potential applications as vaccine adjuvants.
外文关键词：self-assembly； hydrogel； vaccine adjuvant
作者：Wang, Z; Cai, Y; Yi, L; Gao, J; Yang, Z
作者单位：南开大学
期刊名称：CHINESE JOURNAL OF CHEMISTRY
期刊影响因子：1.852
出版年份：2017
出版刊次：7
点击下载：一种吲哚基修饰的短链肽超分子水凝胶疫苗佐剂