中文摘要：研究制备了一种新型纳米铁铝混合羟基磷酸盐，并分析了其理化特征。这种纳米铁铝混合羟基磷酸盐可作为疫苗佐剂，是通过Fe(III) 、Al(III) 氯化物与磷酸钠混合溶液一起沉淀形成的，并采用高压灭菌法进行消毒。制备得到的磷酸盐由扁平状纳米颗粒（20-40 nm）网组成，这些纳米颗粒在水介质中形成二级微米级颗粒。采用X射线能量色散谱分析该纳米羟基磷酸盐的特性及其元素组成，X射线粉末衍射、红外光谱、Zeta电位测量等分析其等电点、蛋白吸收力及在柠檬酸钠溶液中的溶解度。
外文摘要：Adjuvants are substances that, when combined with an antigen in a vaccine formulation, potentiate the immune response against that antigen. Aluminium hydroxyphosphate is among the currently used adjuvants in vaccines, while studies on its iron analogue, ferric hydroxyphosphate, are quite limited. In this article we report on the preparation and physicochemical characterization of novel nanostructured iron and aluminium based mixed hydroxyphosphates as potential vaccine adjuvants, prepared by controlled co-precipitation from mixed solutions of Fe(III) and Al(III) chlorides with sodium phosphate and sterilized by autoclaving. The obtained hydroxyphosphates consisted of a network of platy nanoparticles (20-40 nm in size), which aggregated in aqueous medium to form secondary micron-sized particles. The obtained nanostructured hydroxyphosphates were characterized by energy dispersive X-ray spectroscopy for elemental composition, X-ray powder diffraction, infrared spectroscopy, zeta-potential measurements for determination of isoelectric point, protein adsorption, and dissolution rate in sodium citrate solution.
外文关键词：Aluminium； Iron； Phosphate； Nanoparticles； Vaccines； Adjuvants
作者：Angelova, Nadezhda; Yordanov, Georgi
作者单位：保加利亚索菲亚大学
期刊名称：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING
期刊影响因子：2.71
出版年份：2017
出版刊次：12
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