中文摘要：研究分离和纯化了皂苷类相关化合物saponins Algiox、Sapanox和Pangisan，经证明这些化合物对试验小鼠、鸡、鸡胚的毒性都比较低，可用于制备免疫刺激化合物（ISCOMs），该免疫刺激化合物与包含ISCOMs的皂苷组件A在结构和免疫刺激效率方面都相似。研究利用试验小鼠分析了获取的皂苷类化合物的佐剂作用。结果表明，这些皂苷类物质不仅可以作为兽用疫苗的高效佐剂，也可以作为人类医学领域的高效佐剂进行应用。
 
外文摘要：In recent years, there have been a number of reports on the successful use of immunostimulatory complexes with saponins and viral glycoproteins as veterinary vaccines and in clinical trials for human medicine. The saponins Algiox, Sapanox and Pangisan were isolated and purified by HPLC from Allochrusa gypsophiloides, Saponaria officinalis and Gypsophila paniculata plants in Kazakhstan and they proved to have low toxicity in experiments with mice, chickens and chicken embryos. Algiox, Sapanox and Pangisan can be used to create immunostimulatory complexes (ISCOMs) similar to saponin-Quil-A-containing ISCOMs both in structure and in immunostimulatory efficiency. The adjuvant effect of the obtained saponins was studied by subcutaneous injection of mice with ISCOMs containing these herbal saponins and lipids and glycoproteins of H7N1 influenza virus. Sapanox, Pangisan and Algiox from Kazakhstani plants of the family Caryophyllaceae could be considered an additional source of highly effective adjuvants not only for veterinary vaccines but also for human medicine.
外文关键词：QUILLAJA-SAPONARIA MOLINA; VIRUS-INFECTION; ISCOM MATRIX; ISCOMATRIX(TM); COMPLEXES; MEDICINE; PROMOTES; HUMANS
作者：Turmagambetova, AS; Alexyuk, PG; Bogoyavlenskiy, AP; Zaitseva, IA; Omirtaeva, ES; Alexyuk, MS; Sokolova, NS; Berezin, VE
作者单位：哈萨克斯坦微生物学与病毒学研究所
期刊名称：ARCHIVES OF VIROLOGY
期刊影响因子：2.16
出版年份：2017
出版刊次：12
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