中文摘要：研究开展了猪肺炎支原体的皮下注射和肌肉注射安全性和效率比较分析。结果表明，两种注射方式对猪的胃口均没有不良影响，且平均直肠温度在保持在生理值。免疫组平均每日增重（ADWG）显著高于对照组，而皮下注射组和肌肉注射组之间没有差异；免疫组肺部病变显著低于对照组，且皮下注射组在降低肺部病变程度和肺炎支原体流行程度方面优于肌肉注射组。这些结果表明，无针化的皮下注射是安全的，且在降低疾病流行程度和肺部病变程度方面是有效的，并能提高感染猪场猪只的生产性能。
 
外文摘要：The present study compares the safety and efficacy of a needle-free, intradermal Mycoplasma hyopneumoniae vaccine to an intramuscular one. 420 piglets (21+3 days of age) were randomly assigned to two vaccination groups (intradermal vaccination V1 (n=138), intramuscular vaccination V2 (n=144)) and one unvaccinated control group (CG, n=138). As safety parameters clinical observations, local injection site reactions (ISR) and rectal temperatures were assessed. Average daily weight gain (ADWG) and pneumonic lung lesions (LL) were measured as efficacy parameters. ISRs were minor in V1. After both vaccinations, no adverse impact on appetite was observed and mean rectal temperatures remained within physiological range. ADWG during the fattening period was significantly higher in vaccinated groups (V1: 913.4 g, V2: 924.5 g) compared with CG (875.6 g). No differences in ADWG were observed between V1 and V2. Vaccinated pigs had a significantly reduced mean extent of LL compared with CG. V1 was superior in reducing the extent and prevalence of LL compared with V2. These results reveal that a needle-free intradermal vaccination is safe and efficacious in reducing both the prevalence and extent of lung lesions, as well as in improving performance parameters, in a farrow-to-finish farm with a late onset of M hyopneumoniae infection.
外文关键词：RESPIRATORY SYNDROME VIRUS; LUNG LESIONS; IMMUNE-RESPONSE; PIGS; TRANSMISSION; PROTECTION; INJECTION; STIMULATION; BACTERINS; ADJUVANTS
作者：Beffort, L; Weiss, C; Fiebig, K; Jolie, R; Ritzmann, M; Eddicks, M
作者单位：德国慕尼黑大学
期刊名称：VETERINARY RECORD
期刊影响因子：0.3
出版年份：2017
出版刊次：9
点击下载：猪肺炎支原体皮下注射与肌肉注射的安全性和效率比较