中文摘要：本研究的目的是分析病原DNA拷贝数与儿童肺炎支原体肺炎临床、实验室特征的关系。研究根据支气管肺泡灌洗液(BALF)中肺炎支原体DNA的拷贝数将试验样本分为低MP拷贝组和高MP拷贝组。结果表明，与低MP拷贝组相比，高MP拷贝组72.7%的样本发展为顽固性肺炎，在大环内酯类药物治疗的最初一周内疾病症状没有改观，这一比例在低MP组为41.9%。与低MP组相比，高MP组中有更多的样本出现肺外部症状、肺实变、胸腔积液、出现过敏性症状及血浆IgE、ECP浓度显著升高。结果表明，特应性可能是指示顽固性肺炎支原体肺炎严重性的风险因素。
 
外文摘要：ObjectiveTo investigate the relationship of pathogen DNA copies with clinic and laboratory features among children with Mycoplasma pneumoniae (MP) pneumonia. MethodsA total of 95 enrolled children with MP pneumonia were assigned into the high-MP-load group (>10(6)/mL) and the low-MP-load group (10(6)/mL) according to MP-DNA copies in bronchoalveolar lavage fluid (BALF). Clinical characteristics and any allergy history were collected. Aeroallergens and food allergens were detected with a skin test. Serum IgE and eosinophil cationic protein (ECP) were assessed using enzyme immunoassay. BALF levels of IL-4, IFN-, IL-8 and TNF- were assessed by ELISA. ResultsCompared with the low-MP-load group, 72.7% in the high-MP-load group developed refractory MP pneumonia who failed to respond to at least 1-week treatment with macrolides (72.7% vs 41.9%, P=0.005). More children in the high-load group than those in the low-load group presented with extrapulmonary manifestations, lung consolidation, pleural effusion and atopic conditions including any allergy history, positive findings of aeroallergen test and increased serum IgE and ECP (P<0.05). A significant higher BALF IL-4 level was seen in the high-load group versus the low-load group (23.0011.24 vs 14.68 +/- 7.12; pg/mL; P<0.01). There were no significant differences in BALF levels of IFN-, IL-8 and TNF- between the two groups (P>0.05). ConclusionAtopy may be a risk factor for the presence and severity of refractory MP pneumonia due to the high pathogen load in airway.
外文关键词：atopy； bronchoalveolar lavage fluid； DNA copy numbers； mycoplasma pneumoniae； refractory mycoplasma pneumoniae pneumonia
作者：Bao, YX; Li, J; Tian, Y; Liu, QH; Bao, J
作者单位：上海交通大学
期刊名称：CLINICAL RESPIRATORY JOURNAL
期刊影响因子：2.36
出版年份：2017
出版刊次：11
点击下载：特应性：一种顽固性肺炎支原体肺炎的风险因素？