中文摘要：本研究采用异型流感HA病毒样颗粒对小鼠进行序贯免疫。异型流感HA病毒样颗粒包括源于HA家族1的H1、H8和H13病毒颗粒或源于HA家族2的H3、H4和H10病毒颗粒，或这些不同颗粒的混合物。采用致死剂量的任何一种类型流感（H1、H8、H13、H3、H4、H10）病毒感染小鼠后，免疫小鼠能够得到充分的保护。本研究的免疫策略为通用流感疫苗的发展提供了基础。
外文摘要：Seasonal influenza vaccines have proven to be effective against well-matched viruses in healthy adults. However, rapid accumulation of mutations in the main antigenic surface proteins of influenza can compromise the efficiency of flu vaccines. Occasionally, influenza pandemics arise and present a different type of challenge to current seasonal vaccines. Novel vaccination strategies that can educate the host immune system to generate immune responses focusing on conserved epitopes on theses antigenic surface proteins are crucial for controlling and limiting influenza epidemics and pandemics. In this study, we have sequentially vaccinated mice with heterosubtypic influenza HA virus-like particles (VLPs) harboring H1, H8, and H13 from the HA phylogenetic group 1, or H3, H4, and H10 from the HA phylogenetic group 2, or in various combinations. The immunized animals were fully protected when challenged with lethal doses of heterosubtypic viruses from either phylogenetic group. Our vaccination approach demonstrates a promising strategy for the development of a 'universal influenza vaccine'.
外文关键词：IMMUNE-RESPONSES; HEMAGGLUTININ STEM; SERUM ANTIBODIES; H3N2 VIRUSES; B VIRUSES; VACCINE; RECOGNITION; CHALLENGE; STRAINS; EPITOPE
作者：Luo, Y; Mohan, T; Zhu, WD; Wang, C; Deng, L; Wang, BZ
作者单位：佐治亚州立大学
期刊名称：SCIENTIFIC REPORTS
期刊影响因子：4.26
出版年份：2018
出版刊次：3
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