中文摘要：本研究组已有的研究证实，中药“清肺通络合剂（QTF）”对肺炎支原体肺炎具有显著的治疗效果。本研究分析了“清肺通络合剂”主要成分之一柚皮素对肺炎支原体肺炎的治疗效果及其机理。试验表明，肺炎支原体感染后促炎性细胞因子和转化生长因子β的表达显著增加；柚皮素处理能够通过抑制细胞吞噬相关的炎性细胞因子的表达和肺部纤维化来降低肺部损伤。该结果表明，肺炎支原体感染后，柚皮素通过抑制细胞的自我吞噬作用从而抑制了炎性反应和肺纤维化。
 
外文摘要：Our previous study has shown that Chinese medicine, Qingfei Tongluo formula (QTF), has a significantly therapeutic effect to Mycoplasma pneumoniae (MP) pneumonia (MPP). The aim of this study was to investigate the therapeutic effect and mechanism of naringenin (NRG) on MPP which was an important component of QTF. Here, we studied 124 children with or without MPP and compared inflammatory cytokines and fibrinogen-related protein expression with enzyme-linked immunosorbent assay. We also employed a BALB/c mouse model of MPP and divided the mice into three groups: ctrl (normal control mice), MPP (MP-infected mice), and MPP+ NRG (MP-infected mice treated with NRG). BEAS-2B cells were used to confirm the relationship between autophagy, inflammation, and fibrosis. The results show proinflammatory cytokines (interleukin-[IL-] 6, IL-1 beta, and tumor necrosis factor-a), and transforming growth factor beta (TGF-beta) expression was significantly increased after MP infection from both clinical and animal experiment. In vivo experimental confirmation showed that NRG treatment decreased MPP-induced lung injury in mice by inhibiting autophagy-mediated inflammatory cytokine expression and pulmonary fibrosis. In vitro experiments confirmed it. These results indicate that NRG treatment suppressed the inflammatory response and pulmonary fibrosis by inhibition of autophagy after MP infection.
外文关键词：KAPPA-B; OXIDATIVE STRESS; PATHWAY; INJURY; CELLS; RATS
作者： Lin, Y; Tan, D; Kan, QN; Xiao, Z; Jiang, ZY
作者单位：上海中医药大学
期刊名称：MEDIATORS OF INFLAMMATION
期刊影响因子：3.232
出版年份：2018
出版刊次：5
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