中文摘要：研究应用细菌样颗粒（BLPs）构建了一种鼻内百日咳疫苗的粘膜佐剂，分析了这种佐剂在诱导小鼠血液和粘膜抗体、抗百日咳保护作用方面的效率。结果表明，采用BLPs为佐剂进行常规鼻内免疫能够迅速诱导IgG 和 IgA分泌，并为机体提供了强有效的抗炎症反应保护作用。该结果表明，采用BLPs佐剂的新型鼻内百日咳疫苗能够诱导产生抗百日咳的免疫保护作用。
外文摘要：Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the present study, bacterium-like particles (BLPs) were adopted as a mucosal adjuvant for an i.n. pertussis vaccine and evaluated on the ability to induce serum and mucosal antibodies as well as potency against i.n. challenge in mice. Groups with or without aluminum adjuvant were also evaluated through both i.n. and intraperitoneal inoculations. Vaccination with BLPs via the i.n. route led to rapid IgG and IgA production and provided strong protection against inflammation induced by infection. The results support an i.n. pertussis vaccine with BLPs adjuvant as a promising candidate to elicit protective immunity against whooping cough.
外文关键词：Pertussis vaccine, Intranasal, Adjuvant, Bacterium-like particles, Mucosal immunity
作者：Shi, W; Kou, YM; Jiang, H; Gao, F; Kong, W; Su, WH; Xu, F; Jiang, CL
作者单位：吉林大学
期刊名称：IMMUNOLOGY LETTERS
期刊影响因子：2.86
出版年份：2018
出版刊次：6
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