中文摘要：肺炎支原体可分为MP1和MP2 两种主要的基因型，这两种基因型的主要区别在于P1黏附蛋白基因DNA序列。本研究的目的是探讨MP1亚型肺炎支原体感染与急性肺炎支原体肺炎症状的相关。研究比较了MP1、MP2肺炎支原体感染的流行病学和临床数据，并分析了样本的个体症状。结果表明，所选样本中，MP1亚型肺炎支原体的感染样本为356个，MP2亚型126个。MP2亚型感染样本C反应蛋白中值基线高于MP1亚型。MP1亚型肺炎支原体的样本分布与肺炎支原体感染的症状存在差异。MP2亚型患者出现神经和心血管的症状比较普遍，而MP1亚型在其他症状上表型比较普遍。该结果表明，2种P1亚型肺炎支原体感染具有不同的临床症状，而MP2亚型肺炎支原体感染产生的危害可能要重于MP1亚型。
外文摘要：Mycoplasma pneumoniae (M. pneumoniae) isolates can be classified into two major genetic groups, P1 type 1 (MP1) and P1 type 2 (MP2), based on the DNA sequence of the P1 adhesion protein gene. The aim of our study was to determine if M. pneumoniae P1 genotype is associated with disease manifestation and severity of acute M. pneumoniae infection. We compared epidemiological and clinical data of children infected with either MP1 or MP2. In addition, we separately analysed data of patients presenting with individual manifestations of M. pneumoniae infection. Data of 356 patients infected with MP1 were compared with those of 126 patients infected with MP2. MP2-infected children presented with higher median baseline C-reactive protein levels and were admitted to the hospital more often. The distribution of P1 genotype varied among groups of patients with different manifestations of M. pneumoniae infection. MP2 was more common than MP1 among patients with neurological and cardiovascular manifestations, whereas MP1 was more prevalent in other manifestations. The results from our large cohort indicate that the two P1 subtypes may have different pathogenic potential and that infections with MP2 strains could be more virulent than those with MP1 strains.
 
外文关键词：Mycoplasma pneumoniae； Genotype； Paediatrics； Infection
作者：Berlot, JR； Krivec, U； Praprotnik, M； Mrvic, T； Kogoj, R； Kese, D
作者单位：斯洛文尼亚儿童医院
期刊名称： EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
期刊影响因子：3.712
出版年份：2018
出版刊次：7
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