澳大利亚一家育肥猪场80%的7周龄小猪爆发了呼吸道疾病，并有5%的病猪死亡。病理分析表明，病猪除肺叶顶部和中部表现出化脓性支气管炎并发肠道支原体感染症状外，胸腹腔还表现出纤维素性浆膜炎。进一步分析确定为非流行性猪流感A病毒H1N1亚型。猪肺炎支原体和繁殖与呼吸综合征病毒分子诊断为阴性，而在浆膜中分离得到了猪鼻支原体和副猪嗜血杆菌。研究强调，以往研究低估了猪鼻支原体在病毒感染过程中的并发作用，现在必须引起重视，并阐述导致肺叶顶部肺炎病因并不限于肺炎支原体。母猪接种流感疫苗会遮蔽H1N1亚型；检测结果表明，只有33%左右的仔猪在7周龄具有母源抗体。本研究结果表明，预防断奶仔猪流感病毒A的困难在于缺乏可用于56日龄之前仔猪免疫的权威疫苗。
外文摘要：In a closed farrow-to-finish piglet producing farm 80% of 7-week-old piglets displayed respiratory disease with a 5% mortality rate. In addition to purulent bronchopneumonia in combination with interstitial pneumonia predominantly in the apical and middle lobes, fibrinous serositis was present in the thoracic and abdominal cavities. Further investigations succeeded in confirming the non-pandemic strain of porcine influenza A virus (FLUAVsw) subtype H1avN1. The molecular genetic studies on Mycoplasma (M.) hyopneumoniae and porcine reproductive and respiratory syndrome virus were negative, whereas M. hyorhinis and Haemophilus parasuis were isolated from serous membranes. The possible importance of the underrated M. hyorhinis as a cofactor for viral infections should be emphasized and we demonstrated that the cause of apical lobe pneumonia is not restricted to M. hyopneumoniae. Mother pigs had been vaccinated with an influenza vaccine covering the subtype H1avN1. Only 33% of the examined piglets had maternal antibodies in the 7th week of life. The difficulty of prophylaxis of infections by FLUAVsw in weaners due to lack of vaccine authorization for piglets before their 56th day is reflected by this observation.
外文关键词：Respiratory disease；maternal antibodies；non pandemic H1avN1 infection；vaccination；weaners
作者：Unterweger C, Wochtl B, Spergser J等，
作者单位：澳大利亚维恩兽医大学。
期刊名称：TIERAERZTLICHE PRAXIS AUSGABE GROSSTIERE NUTZTIERE
期刊影响因子：0.305
出版年份：2016
出版刊次：6
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