中文摘要：黏膜免疫是预防黏膜性传播感染的有效方法。与肌肉注射相比，黏膜免疫具有显著的优点，包括可以无创接种、成本低、可以减少血液传染病的风险等，因此大多数人尤其是儿童对黏膜免疫的接受度较高。尽管如此，受黏膜佐剂有效性和安全性的限制，人用疫苗中只有一小部分黏膜疫苗获得批准。然而，基于试验和非综合性的安全性评价等研究策略严重阻碍了黏膜佐剂的发展。因此，急需改变从黏膜佐剂试验创新到理性设计发明整个过程的研究和发展策略。在生命科学、信息科学材料科学交叉发展背景下，发展策略的改变主要依赖对黏膜佐剂活性机制的解读。
外文摘要：Most pathogens access the body via mucosal surfaces. Mucosal vaccination is a highly effective and recommended method to prevent mucosally transmitted infections. Compared with immunization via intramuscular injection, mucosal immunization offers remarkable advantages, including non-invasiveness, low costs and reduced risk of transmission of blood-borne diseases, which make it more acceptable to human beings, especially to young children. However, only few mucosal vaccines are licensed for human, which is mainly due to the deficiency of safe and effective mucosal adjuvants. Adjuvants, as important components of most vaccines, are essential to enhance immunity and induce immune memory. The development of mucosal adjuvants, unfortunately, has been severely hampered by research strategies based on empiric trials and non-comprehensive methods for safety evaluation. Therefore, changing the research and development strategies of mucosal adjuvant field from empiricism based discovery to rational design based invention is highly demanded. The change of strategies mainly depends upon clarification of mechanism of mucosal adjuvant activity though a combination of life science, information science and materials science.
外文关键词：mechanism of action；mucosal adjuvant；rational design；safety； vaccine
作者：Zeng, LB
作者单位：重庆医科大学
期刊名称：HUMAN VACCINES & IMMUNOTHERAPEUTICS
期刊影响因子：2.146
出版年份：2016
出版刊次：9
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