中文摘要：大量研究表明，肺炎支原体感染会向痰或者血液中释放多种细胞因子。然而，以支气管肺泡灌洗液为对象展开的研究较少。本研究的目的是鉴定出与肺炎支原体感染相关的细胞因子，探明急性下呼吸道感染过程中影响细胞因子分泌的可能因素。结果表明，支气管镜检查发现，发热显著影响IL-1 β、IL-4、IL-10和IFN-γ浓度。总而言之，肺炎支原体感染的支气管肺泡灌洗液中IL-1 β、IL-4、IL-10和IFN-γ浓度增加，IL-1 β、IL-4、IL-10和IFN-γ浓度的增加与患者的发热相关。
外文摘要：Many reports have demonstrated that Mycoplasma pneumonia (M. pneumoniae) infection may cause the release of multiple cytokines into sputum or serum samples. However, studies focusing on bronchoalveolar lavage fluid (BALF) samples are scarce. The aim of this study was to identify the cytokines associated with M. pneumoniae infection, and explore the possible factors affecting their secretion during acute lower respiratory tract infection. 60 children with confirmed M. pneumoniae infection complicated with atelectasis, according to chest X-ray or CT scan data, and 20 children with confirmed foreign bodies in the airways (control group) were enrolled. Bronchoalveolar lavage (BAL) samples were obtained by flexible bronchoscopy, and assessed for the presence of interleukin (IL)-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma Interestingly, IL-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, and IFN-gamma amounts were increased in M. pneumonia infected children compared with the control group. Multiple univariate analyses of variance and multiple linear regressions showed that fever during bronchoscopy markedly affected IL-1 beta, IL-4, IL-10 and IFN-gamma concentrations. In conclusion, IL-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10 and IFN-gamma levels were increased in BALF from patients with M. pneumonia. Increased levels of secreted IL-1 beta, IL-4, IL-10 and IFN-gamma were associated with fever in these patients.
外文关键词：Mycoplasma pneumonia； bronchoalveolar lavage；children；cytokines；fever
作者：Lan YL；Chen ZM；Yang DH等
作者单位：浙江大学
期刊名称：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
期刊影响因子：1.075
出版年份：2016
出版刊次：9
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