中文摘要：本研究意在分析肺炎支原体肺炎感染儿童Th1/Th2细胞因子浓度与肺部X光片的关系。结果表明：感染分段性和大叶性支原体肺炎并伴有胸部积液的儿童其呼吸急促和发绀程度要比没有胸部积液或者感染支气管肺炎的儿童要严重；感染分段性和大叶性支原体肺炎的儿童最高体温要比支气管肺炎的儿童高，并且发热和住院的持续时间与肺炎支原体肺炎的严重程度呈正相关。肺炎支原体肺炎儿童胸部影像与Th1/Th2细胞因子的变化显著相关。血液中IL-10和TNF-α可分别作为判断感染分段性或大叶性肺炎支原体肺炎后有无胸腔积液的指标。
外文摘要：Mycoplasma pneumoniae pneumonia (MPP) is one of the most common childhood community-acquired pneumonias, and the chest radiograph usually shows bronchial pneumonia, segmental/lobar pneumonia, or segmental/lobar pneumonia with pleural effusion. The imbalance of Th1/Th2 function after Mycoplasma pneumoniae infection is an important immunological mechanism of MPP. In this study, we aimed to evaluate the correlations between Th1/Th2 cytokine profiles and chest radiographic manifestations in MPP children. Patients and methods: A total of 87 children with MPP were retrospectively reviewed in this study. According to the chest radiographic manifestations, they were divided into the following three groups: bronchial MPP group, segmental/lobar MPP group, and segmental/lobar MPP with pleural effusion group. Clinical features and changes in Th1/Th2 cytokines were further analyzed. Results: The incidence of tachypnea and cyanosis was higher in children with segmental/lobar MPP with pleural effusion than in those with segmental/lobar or bronchial MPP. The peak body temperature of segmental/lobar MPP was higher than that of bronchial MPP, and the duration of fever and hospitalization was positively correlated with the severity of MPP. MPP children's chest radiograph showed a relationship with the changes in Th1/Th2 cytokines. Serum interleukin-4, interleukin-10 (IL-10), interferon-gamma, and tumor necrosis factor-alpha (TNF-alpha) of segmental/lobar MPP were significantly higher than those of bronchial MPP, and serum IL-10 (cutoff value: 27.25 pg/mL) can be used as a diagnostic predictor for segmental/lobar MPP. Serum TNF-alpha and interleukin-6 of segmental/lobar MPP with pleural effusion were significantly higher than those of segmental/lobar MPP without pleural effusion. Serum TNF-alpha (cutoff value: 60.25 pg/mL) can be used as a diagnostic predictor for segmental/lobar MPP with pleural effusion. Conclusion: There were significant correlations between Th1/Th2 cytokine profiles and chest radiographic manifestations in MPP children. Serum IL-10 and TNF-alpha can be used as an optimal predictor for segmental/lobar MPP and segmental/lobar MPP with pleural effusion, respectively.
外文关键词：Mycoplasma pneumoniae pneumonia；Th1/Th2；cytokine； chest radiograph
作者：Zhao, JL；Wang, X； Wang, YS
作者单位：天津市南开医院
期刊名称：THERAPEUTICS AND CLINICAL RISK MANAGEMENT
期刊影响因子：1.903
出版年份：2016
出版刊次：12
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