中文摘要：本研究意在阐明细胞因子与学龄儿童顽固性肺炎支原体肺炎判断之间的关系。研究通过180个临床案例的分析表明：顽固性肺炎支原体肺炎组人血管内皮因子IL-6和IL-10、IFN-γ等细胞因子的浓度显著高于普通肺炎支原体肺炎感染组；IL-10、IFN-γ能有效区分顽固性肺炎支原体肺炎和普通肺炎支原体肺炎，可作为判断学龄儿童感染顽固性肺炎支原体肺炎的重要指标。
外文摘要：Excessive immune response against pathogens may play an important role in refracory Mycoplasma pneumoniae pneumonia (RMPP). The aim of this study was to elucidate the associations between cytokines and the prediction of RMPP in school-aged patients. Retrospective analysis was performed on school-aged children with Mycoplasma pneumoniae pneumonia (MPP) hospitalized in our hospital between January 1, 2011 and December 31, 2015. The clinical charcteristics, including the cytokines in serum between the RMPP group and the general Mycoplasma pneumoniae pneumonia (GMPP) group were compared and the predictive values of RMPP were explored. Of total 180 patients, 115 patients were in the GMPP group, 65 were in the RMPP group. We found the levels of cytokines, including nterleukin (IL)-6, IL-10, interferon gamma (IFN-gamma) in RMPP group were significantly higher than those in GMPP group (P < 0.01). In ROC curve analysis, IL-10 and IFN-gamma were useful for differentiating patients with RMPP from those with GMPP. Logistic regression analysis showed that the IL-10 >= 3.65 pg/ml and IFN-gamma >= 29.05 pg/ml were significant predictors regarding to RMPP. Additionally, a positive correlation between serum IL-10 and IFN-gamma concentrations was observed. Conclusions: IL-10 and IFN-gamma could be used as the good predictors of RMPP in school-aged children.
外文关键词：MANIFESTATIONS; PREDNISOLONE; EPIDEMIOLOGY; PATHOGENESIS; INFECTIONS；DISEASES
作者：Zhang, YY; Mei, SF; Zhou, YL; Huang, MX; Dong, GJ; Chen, ZM
作者单位：浙江大学儿童医院
期刊名称：SCIENTIFIC REPORTS
期刊影响因子：5.228
出版年份：2016
出版刊次：11
点击下载：细胞因子是判断学龄儿童是否感染顽固性肺炎支原体肺炎的重要指标