中文摘要：本研究分析了遗传性过敏儿童和非过敏儿童感染肺炎支原体肺炎后体内IL-17水平的变化情况，分别测定了急性感染阶段和恢复阶段IL-17的水平。结果表明：过敏儿童组恢复阶段的血浆IL-17水平显著高于急性感染阶段，过敏组恢复阶段的IL-17水平也显著高于其它感染组临床恢复期的水平；过敏组的急性气喘发作率也更高。因此，血浆IL-17水平与气喘相关，可作为过敏性肺炎支原体肺炎感染后发生急性哮喘的指示性指标。
外文摘要：As previous study showed that Mycoplasma pneumoniae (MP) induced a cellular immune response associated with interleukin-17 (IL-17), we designed this study to explore IL-17 in MP pneumonia patients with atopic sensitization and 144 patients were evaluated and divided into
three groups: atopic MP pneumonia group (n = 38), non-atopic MP pneumonia group (n = 74), and atopic non-MP pneumonia group (n = 32). Serum IL-17 was measured at admission acute phase and at recovery phase. We found IL-17 levels only in the atopic MP pneumonia group that were significantly higher at recovery phase than at acute phase, and its levels were also higher in the atopic MP pneumonia group than the other two groups at clinical recovery phase. In addition, acute asthma attack was higher in the atopic MP pneumonia group. Therefore, IL-17 should be related with asthma and it can be a good marker warning an acute asthma attack in atopic MP pneumonia. Necessary measures can be taken as prevention.
 
外文关键词：interleukin-17； Mycoplasma pneumoniae pneumonia；atopy；asthma
作者：Wang, ZH; Li, XM; Wang, YS; Guo, ZY
作者单位：天津南开医院
期刊名称：INFLAMMATION
期刊影响因子：2.618
出版年份：2016
出版刊次：12
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