中文摘要：本研究旨在分析氢氧化铝（AH）和不同品系遗传差异对脑膜炎球菌A群和W群双价外囊泡疫苗免疫效应的影响。结果表明，加入AH佐剂能够提高抗外囊泡的Ig G浓度以及血清杀菌活性。
外文摘要：Meningococci (Neisseria meningiditis) of serogroups A and W have caused large epidemics of meningitis in sub-Saharan Africa for decades, and affordable and multivalent vaccines, effective in all age groups, are needed. A bivalent serogroup A and W (A + W) meningococcal vaccine candidate consisting of deoxycholate-extracted outer membrane vesicles (OMV) from representative African disease isolates was previously found to be highly immunogenic in outbred mice when formulated with the adjuvant aluminium hydroxide (AH). OMV has been shown to have inherent adjuvant properties. In order to study the importance of AH and genetical differences between mice strains on immune responses, we compared the immunogenicity of the A + W OMV vaccine when formulated with or without AH in inbred C57BL/6J and BALB/cJ mice (Th1 and Th2 dominant strains, respectively). The immunogenicity of the vaccine was found to be comparable in the two mice strains despite their different immune profiles. Adsorption to AH increased anti-OMV IgG levels and serum bactericidal activity (SBA). The immune responses were increased by each dose for the adsorbed vaccine, but the third dose did not significantly improve the immunogenicity further. Thus, a vaccine formulation with the A and W OMV will likely benefit from including AH as adjuvant.
 
外文关键词：Meningococcal vaccine；aluminium hydroxide；outer membrane vesicles；BALB/c；C57BL/6
作者：Tunheim, G; Arnemo, M; Nss, LM; Norheim, G; Garcia, L; Cardoso, D; Mandiarote, A; Gonzalez, D; Sinnadurai, K; Fjeldheim, AK; Bolstad, K; Rosenqvist, E
作者单位：挪威国家公共卫生研究院
期刊名称：APMIS
期刊影响因子：1.933
出版年份：2016
出版刊次：11
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