中文摘要：本研究利用鸟分歧杆菌（MIP）作为卡介苗疫苗增强剂增强卡介苗介导的免疫反应，从而对机体产生更高的保护作用。试验表明，MIP增强剂通过气溶胶免疫比皮下免疫更有效。采用MIP增强剂能够诱导机体产生更高水平的促炎性细胞因子，如IFN-γ、IL-12和IL-17；提高功能性T细胞的比例。该结果表明，MIP作为增强剂能够提高卡介苗的免疫保护作用，是一种经济、有效的控制结核病的方法。
外文摘要：BCG, the only approved vaccine protects against severe form of childhood tuberculosis but its protective efficacy wanes in adolescence. BCG has reduced the incidence of infant TB considerably in endemic areas; therefore prime-boost strategy is the most realistic measure for control of tuberculosis in near future. Mycobacterium indicus pranii (MIP) shares significant antigenic repertoire with Mtb and BCG and has been shown to impart significant protection in animal models of tuberculosis. In this study, MIP was given as a booster to BCG vaccine which enhanced the BCG mediated immune response, resulting in higher protection. MIP booster via aerosol route was found to be more effective in protection than subcutaneous route of booster immunization. Pro-inflammatory cytokines like IFN-gamma, IL-12 and IL-17 were induced at higher level in infected lungs of 'BCG-MIP' group both at mRNA expression level and in secretory form when compared with 'only BCG' group. BCG-MIP groups had increased frequency of multifunctional T cells with high MFI for IFN-gamma and TNF-alpha in Mtb infected mice. Our data demonstrate for the first time, potential application of MIP as a booster to BCG vaccine for efficient protection against tuberculosis. This could be very cost effective strategy for efficient control of tuberculosis.
外文关键词：Tuberculosis;Mycobacterium indicus pranii;Booster vaccine;Poly-functional T cells;Protection
作者：Saqib, M; Khatri, R; Singh, B; Gupta, A; Kumar, A; Bhaskar, S
作者单位：印度国家免疫研究所
期刊名称：TUBERCULOSIS
期刊影响因子：2.952
出版年份：2016
出版刊次：12
点击下载：一种能够促进卡介苗诱导的免疫反应从而对肺结核动物模型产生保护作用的鸟分歧杆菌免疫增强剂