中文摘要：本发明公开了一种靶向细胞内核的蛋白组成及其制备方法，尤其是一种包含融合蛋白的疫苗；该融合蛋白能够促进疫苗靶向细胞自噬通路。该融合蛋白由SQSTM1/p62和共价化合物组成，在疫苗组合中可诱导产生免疫反应，尤其是T细胞免疫反应。
外文摘要：The present invention relates to compositions and methods for targeting proteins to intracellular compartments. In particular, the present invention provides vaccine compositions comprising fusion proteins that target the vaccines to the autophagy pathway.
NOVELTY - A fusion protein comprising sequestosome 1 (SQSTM1)/p62 and a conjugate, is new.
USE - The fusion protein is useful in vaccine composition for inducing an immune response, preferably T-cell immune response in a subject towards an antigen chosen from an antigen derived from virus, preferably HIV Gagp24, and a cancer antigen (all claimed). The vaccine is useful for preventing and treating infection caused by microorganisms and virus induced cancers. 

 
主权项：(1) a nucleic acid encoding the polypeptide or fusion protein; and (2) a host cell comprising the nucleic acid.
申请号：WO2016IB01017
公开/公告号：WO2016207730A1
申请日：2016-06-22
公开/公告日：2016-12-29
申请/专利权人：THE UNIV OF OSLO
发明/设计人：ANDERSEN ARAM NIKOLAI; BOGEN BJARNE; OYNEBRATEN INGER
分类号：A61K39/0011; A61K39/21; C07K14/161; C07K14/4748; C07K2319/06; C12N2740/16234
主分类号：A61K38/17; A61K39/00; A61K39/21; C07K14/16; C07K14/47
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