中文摘要：本发明公开了一种新的融合多肽及其应用，该融合多肽涉及一种源于线虫传多面体病毒的融合壳蛋白、利用该融合蛋白组成的病毒样颗粒及其应用。该病毒样颗粒能够释放和（或）封闭目标分子，并能应用于制药、农业和兽医领域。该病毒样颗粒可用于制备疫苗、疫苗佐剂、药物或显像剂，或作为诊断剂、追踪剂，或用于减少或提高体外化合物的暴露，可治疗、预防、诊断多种病理性疾病并进行显像。
 
外文摘要：The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.
NOVELTY - A virus-like particle comprising Nepovirus coat protein, is new.
USE - The virus-like particle is useful for producing e.g. vaccines, adjuvants, drugs or imaging agents, used as a diagnostic agent and tracer, useful for reducing or improving exposure of compound in vivo, and treating, preventing, diagnosing or imaging various pathologies.
主权项：(1) molecule comprising Nepovirus coat protein conjugated to a compound, preferably in C-terminal or in N-terminal of the coat protein; 
(2) pharmaceutical composition comprising one or more virus-like particles or above-mentioned molecule; 
(3) method (M1) for producing the molecule involves expressing a nucleic acid construct encoding the molecule in host cell or an in vitro expression system, and collecting the expressed protein;
(4) method (M2) for producing virus-like particles; and 
(5) vector compri! sing the nucleic acid.
申请号：EP20150306396
专利号： EP3141600A1
公开/公告号： EP3141600A1
申请日：2015-09-11
公开/公告日：2017-03-15
申请/专利权人：AGRONOMIQUE INST NAT RECH [FR]; UNIVERSITÉ DE STRASBOURG [FR]; CENTRE NAT RECH SCIENT [FR] +
发明/设计人：BELVAL, L;DEMEANGEAT, G;HEMMER, C;RITZENTHALER, C;DEMANGEAT, G
分类号：C07K14/005; C07K2319/00; C07K2319/60; C12N2770/18022; C12N2770/18023; C12N7/00
主分类号：C07K14/085; C12N15/62; C12N7/00
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