中文摘要：本发明公开了一种具有较好生物适应性的免疫佐剂，该佐剂由碳酸钙，最好是羟基磷灰石组成，颗粒大小在40 nm到1800nm之间；同时公开了一种由该佐剂制成的药物以及疫苗。杆状的碳酸钙与球形碳酸钙相比能够诱导产生更高浓度的IL-1β，但两者产生的抗原反应相当。
外文摘要：Provided is an improved biocompatible immune adjuvant. More specifically, provided are: an immune adjuvant that comprises calcium phosphate, preferably hydroxyapatite, having an average particle size of about 40 nm exclusive to about 1800 nm exclusive; a medicine that comprises this immune adjuvant; and a vaccine that comprises this immune adjuvant. Rod-shaped HAp induced inflammasome-dependent IL-1β production in vitro more strongly than spherical HAp. In WT mice, however, spherical HAp and rod-shaped HAp induced equivalent antigen responses.
NOVELTY - An immunological adjuvant comprising calcium phosphate having an average particle size of 40-1800 nm, is new.
USE - The immunological adjuvant is useful in a pharmaceutical or vaccine for prophylaxis or treatment of disease (all claimed). The vaccine is useful as influenza virus, Japanese encephalitis, diphtheria-pertussis-tetanus-polio mixture (DPTP), diphtheria-pertussis-tetanus mixture (DPT), diphtheria-tetanus mixture (DT), measles, rubella, polio, Bacillus Calmette-Guerin (BCG), hepatitis A, hepatitis B, rabies, tetanus toxoid, diphtheria toxoid, pneumococcus, Weil's disease, varicella, mumps, yellow fever, rotavirus, Haemophilus influenzae type b, human papillomavirus (HPV), respiratory syncytial (RS) virus (RSV), cytomegalovirus (CMV), norovirus, herpes simplex virus vaccine.
ADVANTAGE - The immunological adjuvant has excellent biocompatibility, high antigen-specific antibody response, and increased neutralizing capacity. The rod-like calcium phosphate induces more stronger inflammasome-dependent interleukin 1 beta (IL-1 beta ) production than spherical calcium phosphate.
 
申请号：WO2016JP04250
公开/公告号：WO2017047095A1
申请日：2016-09-16
公开/公告日：2017-03-23
申请/专利权人：NAT INST BIOMEDICAL INNOVATION (NABI-N); SOFSERA CORP (SOFS-N)
发明/设计人：HAYASHI, M;ISHII, K;KOGAI, Y;NOMI, D;KAWABE, K K
分类号：A61K39/00; A61K39/39
主分类号：A61K39/00; A61K39/39
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