中文摘要：本发明公开了一种嘌呤共轭化合物，其组成为： A、L1、L2、X1、R1、R2、R3或其盐类。该化合物具有免疫刺激特性，可用作疫苗佐剂。本发明同时公开了这种共轭化合物及其盐类的制备方法。
外文摘要：The present specification relates to adenine conjugate compounds represented by the formula (1), wherein A, L1, L2, X1, R1, R2, R3, and m are as defined herein, or their pharmaceutically acceptable salts. Compounds of formula (1) have immunostimulating properties and may therefore be useful in therapy, for example as vaccine adjuvants. The present specification also relates to a process for preparing adenine conjugate compounds and pharmaceutically acceptable salts thereof, and to pharmaceutical compositions comprising adenine conjugate compounds and their pharmaceutically acceptable salts.
NOVELTY - Adenine conjugate compounds (I) are new.
USE - (I) are useful: as a vaccine adjuvant in treatment or prevention of cancer; and for enhancing immunostimulating activity of an antigen (all claimed). Test details are described but no results given.
 
主权项：Adenine conjugate compounds of formula (I) and their salts are new.L1, L2 = alkylene; R1, R4 = H or alkyl; R2 = optionally substituted alkyl; R3 = H, halo, alkyl or alkoxy; X1 = single bond, O, S, SO, SO2, NR4 or CONR4; A = monocyclic aromatic carbocyclyl or 5-6 membered aromatic heterocyclic ring comprising 1-4 heteroatoms comprising 1-4 N, O or S; andm = 0 or 1, where the dotted line represents a single bond or a double bond.
 
申请号：WO2016JP04375
公开/公告号：WO2017056494A1
申请日：2016-09-28
公开/公告日：2017-04-06
申请/专利权人：SUMITOMO DAINIPPON PHARMA CO LTD [JP]; ASTRAZENECA AB [SE]
发明/设计人：BAN HITOSHI [JP]; NISHIO YUKIHIRO [JP]; MALYALA PADMA [US]; MURALIDHARA BILIKALLAHALLI K [US]; WONG MARCUS [US]
分类号：A61K31/522; A61K47/48023; A61K47/488; C07D473/34
主分类号：A61K31/522; A61K47/54; A61K47/69; A61P35/00; C07D473/34
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