中文摘要：本发明公开了一种提高提高病毒和细菌性疫苗稳定性的方法。本发明所述的疫苗被包裹在一个具有稳定剂的病毒样颗粒中，稳定剂为糖醇（如山梨（糖）醇）和降解明胶。明胶的分子量为10000千道尔顿或者更小。本发明提供的方法能够持续提高疫苗的热稳定性。
外文摘要：The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in VLPs with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins. Preferably the gelatin has an average molecular weight of 10,000 kilodaltons or less. These vaccines have a substantially improved thermostability as well as long term stability. The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a vaccine of the invention to patients.
NOVELTY - A vaccine comprising virus-like particles (VLPs) that encapsulate an immunogenic component and a stabilizing agent, is new.
USE - The vaccine is useful for treating or preventing an infection in a mammal, preferably an infant, toddler, adolescent, adult or senior (all claimed), where the infection is caused by bacteria, virus, and parasite.
ADVANTAGE - The administration of vaccine does not generate a general inflammatory response or local inflammation at the site of administration. The vaccine has improved thermostability and long-term stability, excellent immunogenicity, no side effects, and effectiveness over periods of time.
主权项：(1) method (M1) for treating or preventing an infection, which involves determining the amount of the vaccine to be administered and administering the amount of the vaccine to a mammal; and
(2) method (M2) for producing the vaccine.
申请号：US201615257143
公开/公告号：WO2017041083A1
申请日：2016-09-06
公开/公告日：2017-03-09
申请/专利权人：INVENTPRISE LLC (INVE-N)
发明/设计人：KAPRE, S V
分类号：A61K39/12; A61K47/10; A61K47/42; A61K9/0019; A61K9/19; C07K14/005; C12N7/00; A61K2039/5258; C12N2710/20034; C12N2730/10123; C12N2730/10142
主分类号：A61K39/12; A61K47/10; A61K47/42; A61K9/19; C07K14/005; C12N7/00
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