中文摘要：本发明公开了一种制备百日咳疫苗的方法，尤其是一种脱毒百日咳疫苗，该疫苗由脱毒百日咳毒素、脱毒百日咳杆菌脂多糖和脱毒百日咳腺苷酸环化酶毒素组成。本发明同时公开了这种疫苗的制作方法和免疫方法。
 
外文摘要：The invention is directed to a method for the production of a pertussis vaccine and, in particular, a detoxified pertussis vaccine comprising detoxified pertussis toxin (PT), detoxified pertussis lipopolysaccharide (P-LPS), and detoxified pertussis adenylate cyclase toxin (P-ACT). The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a detoxified vaccine to patients.
NOVELTY - Vaccine comprises a detoxified pertussis toxin protein, an enzyme treated pertussis lipopolysaccharides (LPS), and a detoxified pertussis adenylate cyclase protein.
USE - The vaccine is useful for treating or preventing infection caused by B.pertussis, or B.parapertussis or protecting against infection caused by B.pertussis, or B.parapertussis or multiple serotype or strains of B.pertussis, or B.parapertussis in mammal by producing immune response against infection in mammal. The mammal is an adult or child (all claimed). 
ADVANTAGE - The vaccine maintains intrinsic adjuvant activity, and produces little to no side effects including absence of a fever of mammal attributable a vaccination and/or absence of an inflammation at the site of administration of the vaccine.
 
申请号：US201615264890
公开/公告号：US2017000882A1
申请日：2016-09-14
公开/公告日：2017-01-05
申请/专利权人：INVENTPRISE LLC (INVE-N)
发明/设计人：KAPRE, S V
分类号：A61K39/099; A61K39/39; C12Y406/01001; A61K2039/55; A61K2039/55544; A61K2039/55572
主分类号：A61K39/02; A61K39/39
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