中文摘要：本发明公开了一种疫苗佐剂。该佐剂大小为10-300nm，包含一个分子核，该分子核由绑定半分子构成；一个疏水基团通过绑定半分子绑定到分子核上；同时，一个带正电的基团通过绑定分子绑定到分子核上，该绑定分子全部由带正电的分子组成。该分子核可以是一种聚合物或一种聚合物类材料，如壳聚糖或支链淀粉、植物糖原或糖元等高度支化的α-葡聚糖。
外文摘要：The present invention provides a new adjuvant for administering vaccines.
NOVELTY - Composition comprises an adjuvant comprising a core molecule comprising binding moieties, where the adjuvant is 10-300 nm in size, a hydrophobic group bound to the core molecule through the binding moieties, and a positively charged group bound to the core molecule by the binding moieties comprising an overall positively charged molecule. The core is dendrimer, dendrimer-like material, chitosan, or highly branched alpha -D-glucan e.g. amylopectin, phytoglycogen or glycogen.
USE - The composition is useful for treating a disease comprising influenza in an animal which is a human, in an immunotherapy (all claimed), and for delivering genes into cells. Test details are described but no results given.
ADVANTAGE - The composition enhances the efficacy of DNA vaccines as well as gene therapy, and utilizes the adjuvant which is adsorptive and biodegradable and provides transient inflammatory response and resolves more quickly than the injection site reaction induced by aluminum hydroxide adjuvant.
申请号：US201514935376
公开/公告号：US2017128567A1
申请日：2015-11-07
公开/公告日：2017-05-11
申请/专利权人：PURDUE RESEARCH FOUNDATION
发明/设计人：HOGENESCH, H;YAO, Y
分类号：A61K39/39
主分类号：A61K39/39
点击下载：疫苗佐剂