中文摘要：本发明公开了一种疫苗佐剂系统，该佐剂由以下成分组成：（1）一种poly I:C聚核苷酸佐剂，（2）一种脂质佐剂，（3）两性分子化合物，（4）一种疏水载体。本发明同时提供了一种疫苗组成，该疫苗不含水分，包含一种或多种抗原成分。本发明同时公开了该疫苗及其佐剂的使用方法，包括诱导抗体，诱导细胞免疫反应，以及利用该疫苗治疗疾病、机体失调，改善机体功能等方面的作用。
外文摘要：The present disclosure provides adjuvanting systems comprising: (a) a polyI:C polynucleotide adjuvant; (b) a lipid-based adjuvant;(c) an amphipathic compound; and (d) a hydrophobic carrier. Also provided are vaccine compositions that are water-free or substantially free of water, which comprise the same components together with one or more antigens. The disclosure also provides uses for such compositions in inducing an antibody (humoral) and/or cell-mediated immune response and methods for their use in the treatment of a disease, disorder or ailment ameliorated by an antibody and/or cell-mediated immune response.
NOVELTY - Adjuvanting system comprises: (a) a polyI:C polynucleotide adjuvant; (b) a lipid-based adjuvant; (c) an amphipathic compound; and (d) a hydrophobic carrier.
USE - The adjuvanting system, composition, and method are useful for treating or preventing disease or disorder ameliorated by an antibody immune response and/or cell-mediated immune response, disease caused by bacteria, virus, fungus, parasite, allergen, or a tumor cell that expresses the antigen, or neurodegenerative disease, where the neurodegenerative disease is associated with expression of the antigen; for neutralizing toxin, virus, bacterium or allergen, wit antibody produced against the antigen; for inducing antibody response and/or cell-mediated immune response to the antigen in the subject; and for treating influenza, respiratory tract infection caused by human respiratory syncytial virus, pertussis, anthrax, malaria, or cancer. The kit is useful for preparing composition that is water-free or substantially free of water (all claimed).
ADVANTAGE - Provided are adjuvanting systems and vaccine compositions for generating strong humoral and cell-mediated immune responses against a variety of antigens, and for enhancing antigen-specific immunogenicity.

 
主权项：(1) a composition comprising the adjuvanting system and an antigen, where the composition is water-free or substantially free of water;
(2) a method comprising administering the composition to a subject;
(3) a method for neutralizing a toxin, virus, bacterium or allergen, with an antibody, comprising administering the composition to a subject; and
(4) a kit comprising, in one or more separate containers, a polyI:C polynucleotide adjuvant; a lipid-based adjuvant; an amphipathic compound; and a hydrophobic carrier, where: (i) the polyI:C polynucleotide adjuvant; the lipid-based adjuvant; the amphipathic compound; and the hydro! phobic carrier are each in a separate container; (ii) the poly I:C poly nucleotide adjuvant; the lipid-based adjuvant; and the amphipathic compound are together in a first container and the hydrophobic carrier is in a second container; (iii) the polyI:C polynucleotide adjuvant and the lipid-based adjuvant are together in a first container; the amphipathic compound is in a second container; and the hydrophobic carrier is in a third container; (iv) the polyI:C polynucleotide adjuvant and the lipid-based adjuvant are together in a first container and the amphipathic compound and the hydrophobic carrier are together in a second container; or (v) the polyI:C polynucleotide adjuvant is in a first container, the lipid-based adjuvant is in a second container, and the amphipathic compound and the hydrophobic carrier are together in a third container.
 
申请号：WO2016CA51324
公开/公告号：WO2017083963A1
申请日：2016-11-15
公开/公告日：2017-05-26
申请/专利权人：IMMUNOVACCINE TECHNOLOGIES INC (IMMU-N)
发明/设计人：WEIR, G M;MACDONALD, L D;LIWSKI, R;MANSOUR, M
分类号：A61K39/07; A61K39/12; A61K39/39; A61K2039/55516; A61K2039/55561; A61K2039/55572; C12N2710/20034; C12N2760/16134
主分类号：A61K39/39; A61P37/04
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