中文摘要：本发明公开了一种具有免疫增强作用的佐剂，该佐剂为一种包含视黄酸或其类似物的水包油乳剂。这种水包油乳剂能够提高粘膜免疫反应。
外文摘要：Retinoic acid, or an analogue thereof, is delivered within an oil-in-water emulsion to provide an improved immunological adjuvant.
NOVELTY - Oil-in-water emulsion comprises retinoic acid, or its analog.
USE - Oil-in-water emulsion used as immunological adjuvant, and used in kit for preparing immunogenic composition (all claimed).
ADVANTAGE - The oil-in-water emulsion provides enhanced mucosal immune response.
主权项：DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for:
(1) an injectable oil-in-water emulsion, which comprises retinoic acid, or its analog;
(2) an immunogenic composition, which comprises an oil-in-water emulsion including retinoic acid, or its analog and an immunogen;
(3) a kit for preparing an immunogenic composition, which comprises first container including an oil-in-water emulsion and second container including an immunogen;
(4) a syringe, which has an attached needle, and contains an oil-in-water emulsion;
(5) a method for preparing oil-in-water emulsion, whic! h involves using retinoic acid, or its analog for microfluidization;
(6) a method for preparing an immunogenic composition, which involves mixing an oil-in-water emulsion with solution or suspension of immunogen; and
(7) an oil/surfactant mixture, which comprises squalene and/or tocopherol and retinoic acid, or its analog.
申请号：WO2016EP82096
公开/公告号：WO2017108902A1
申请日：2016-12-21
公开/公告日：2017-06-29
申请/专利权人：NOVARTIS AG (NOVS-C)
发明/设计人：DORO, U;BRITO, L;OHAGAN, D;VENDETTI, S
分类号：A61K31/203; A61K39/39; A61K45/06; A61K47/44; A61K2039/55566
主分类号：A61K31/07; A61K31/203; A61K33/00; A61K39/00; A61K39/39; A61K47/44
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