一种具有免疫促进作用的佐剂及其应用

IMMUNOSTIMULATORY ADJUVANTS AND USES THEREOF

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中文摘要:本发明公开了一种由乙酰化三唑甘露二糖衍生物组成的肌肉免疫促进剂,利用该衍生物制备的药物或营养促进剂以及这种免疫促进剂、药物和营养促进剂在调控Th 或Treg细胞介导的免疫反应等方面的应用。
外文摘要:

The present invention relates to im-munostimulatory compounds of the following formula, combinations thereof, pharmaceutical or nutritional preparations comprising the same, as well as their use for modulating T helper (Th) and T regulatory (Treg) cell -mediated immune responses.NOVELTY - Acetylated trivalent mannobiose-triazole derivatives (I) are new.USE - (I) are useful: as an adjuvant of a vaccine; in treating a condition which can be prevented or treated by inducing a T-regulatory and/or T-helper(Th)-1-type, and/or inhibiting Th-2-type immune response, where the condition is type-I immediate atopic allergy, atopic eczema/dermatitis syndrome, allergic asthma, allergic rhinitis, allergic urticaria, food allergy, venom allergy, and allergic rhinoconjunctvitis, infectious disease, and cancer; as immunostimulatory composition; and as a food additive or nutritional preparation (all claimed). Test details are described but no results given.


主权项:

Acetylated trivalent mannobiose-triazole derivatives of formula (I) and their salts are new.
n = 0-2.
An INDEPENDENT CLAIM is also included for an immunostimulatory composition comprising at least one of (I), and a carrier consisting of trans! dermal carriers, transmucosal carriers, oral carriers, parenteral carriers, carriers for depot formulations, and carriers for extended release formulations.


申请号:WO2016FI50908
公开/公告号:WO2017109288A1
申请日:2016-12-21
公开/公告日:2017-06-29
申请/专利权人:TURUN YLIOPISTO (TURU-N); ABO AKAD (ABOA-N)
发明/设计人:RAHKILA, J;LEINO, R;SAVOLAINEN, J
分类号:C07H15/26
主分类号:A61K31/7056; A61P37/04; C07H15/26
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  1. 编译服务:动物支原体学
  2. 编译者:程金花
  3. 编译时间:2017-08-21