外文摘要:
The present invention relates to im-munostimulatory compounds of the following formula, combinations thereof, pharmaceutical or nutritional preparations comprising the same, as well as their use for modulating T helper (Th) and T regulatory (Treg) cell -mediated immune responses.NOVELTY - Acetylated trivalent mannobiose-triazole derivatives (I) are new.USE - (I) are useful: as an adjuvant of a vaccine; in treating a condition which can be prevented or treated by inducing a T-regulatory and/or T-helper(Th)-1-type, and/or inhibiting Th-2-type immune response, where the condition is type-I immediate atopic allergy, atopic eczema/dermatitis syndrome, allergic asthma, allergic rhinitis, allergic urticaria, food allergy, venom allergy, and allergic rhinoconjunctvitis, infectious disease, and cancer; as immunostimulatory composition; and as a food additive or nutritional preparation (all claimed). Test details are described but no results given.
主权项:
Acetylated trivalent mannobiose-triazole derivatives of formula (I) and their salts are new.
n = 0-2.
An INDEPENDENT CLAIM is also included for an immunostimulatory composition comprising at least one of (I), and a carrier consisting of trans! dermal carriers, transmucosal carriers, oral carriers, parenteral carriers, carriers for depot formulations, and carriers for extended release formulations.
申请号:WO2016FI50908
公开/公告号:WO2017109288A1
申请日:2016-12-21
公开/公告日:2017-06-29
申请/专利权人:TURUN YLIOPISTO (TURU-N); ABO AKAD (ABOA-N)
发明/设计人:RAHKILA, J;LEINO, R;SAVOLAINEN, J
分类号:C07H15/26
主分类号:A61K31/7056; A61P37/04; C07H15/26
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