中文摘要：本发明公开了一种可增强疫苗免疫反应或诱导免疫反应的方法，包括与疫苗同时使用或在疫苗免疫后使用的佐剂，这种佐剂能够为机体提供一定的免疫保护作用。所述佐剂是从人骨髓间充质干细胞分离得到的。该方法能够降低机体B细胞内TNF-α的表达水平，降低机体B细胞的数量，提高CD4+：CD8+T细胞的比例，提高交换记忆B细胞的数量。
 
外文摘要：The present invention provides a method of enhancing an immune response to a vaccine by administering a vaccine and a population of isolated allogeneic human mesenchymal stem cells. The present invention also provides kits comprising a vaccine in a first container and a population of isolated allogeneic human mesenchymal stem cells in a second container.
NOVELTY - Method of enhancing a subject's immune response to a vaccine or inducing an immune response in a subject or non-responding subject, involves administering concurrently or sequentially the vaccine and an adjuvant in immunoprotective amounts to the subject, where the adjuvant is a population of isolated allogeneic human mesenchymal stem cells.
USE - The method is useful for enhancing a subject's immune response to a vaccine or inducing an immune response in a subject or non-responding subject. The subject is a human or non-human animal. The non-human animal is a dog. The human subject exhibits symptoms of aging frailty and inflammaging (all claimed).
ADVANTAGE - The method decreases the intracellular TNF- alpha expression in B cells of the subject by at least two-fold as compared to the TNF- alpha expression levels in B cells, and decreases the number of exhausted B cells in the subject by at least two-fold as compared to the number of exhausted B cells, and increases the CD4+:CD8+ T cell ratio in the subject by at least two-fold as compared to the CD4+:CD8+ T cell ratio, and increases the number of switched memory B cells in the subject by at least two-fold as compared to the number of switched memory B cells in the subject before administration of the adjuvant.
主权项：An INDEPENDENT CLAIM is included for a kit having at least 2 containers, where the vaccine is present in a first container and the adjuvant is present in a second container.
申请号：WO2017US16200
公开/公告号：WO2017136539A1
申请日：2017-02-02
公开/公告日：2017-08-10
申请/专利权人：HARE J M (HARE-I); LANDIN A M (LAND-I)
发明/设计人：HARE, J M; LANDIN, A M
分类号：A61K35/28; A61K2039/555
主分类号：A61K35/28
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