中文摘要：本发明公开了一种流感疫苗的组成及制备方法，其特征是一个包含流感抗原基因的重组腺病毒载体，能够诱导产生广泛的抗流感病毒A和B的免疫反应，能够实现多重免疫；这种腺病毒载体是一种缺陷型腺病毒载体，包含一个缺失片段的E2b基因。
 
外文摘要：Methods for constructing and producing a recombinant adenovirus based vector vaccine containing multiple influenza antigen genes for use in generating broad based immune responses against influenza A and B viruses and that allows for multiple vaccinations in individuals with preexisting immunity to adenovirus are described. Specifically, the recombinant adenovirus based vector is a replication defective adenovirus vector comprising a deletion in an early 2b (E2b) gene.
NOVELTY - A composition comprises a replication defective adenovirus vector comprising a deletion in an E2b gene region; and a nucleic acid sequence encoding an influenza A target antigen and an influenza B target antigen.
USE - The composition is used for generating an immune response against an influenza A target antigen and an influenza B target antigen (claimed).
ADVANTAGE - Methods and compositions for enhanced therapeutic response to complex diseases such as infectious diseases are provided.
主权项：(1) generating an immune response against an influenza A target antigen and an influenza B target antigen in an individual by administering a composition defined above; and
(2) constructing a universal influenza vaccine vector by inserting nucleic acids encoding an influenza A target antigen and an influenza B target antigen into a replication defective adenovirus vector, where the adenovirus vector has a deletion in the E2b region.
申请号：WO2017US13480
公开/公告号：WO2017123976A1
申请日：2017-01-13
公开/公告日：2017-07-20
申请/专利权人：ETUBICS CORP (ETUB-N)
发明/设计人：BALINT, J;JONES, F R;RICE, A;GABITZSCH, E;LATCHMAN, Y
分类号：A61K39/0011; A61K39/12; A61K39/23; A61K2039/5158; A61K2039/5254; A61K2039/5256; A61K2039/55522; C12N2760/16134; C12N2760/16234
主分类号：A61K39/00; A61K39/12; A61K39/145; A61K39/23; C12N15/00
点击下载：一种流感疫苗的组成及制备方法