中文摘要：本发明公开了一种颗粒的粘膜粘着剂载体系统，该系统由纳米支架组成，所述纳米支架包含一个纳米纤维层，该纳米纤维层的厚度在0.1-1000µm间，支架载有物质颗粒；粘膜粘着层或至少其表面与纳米支架交叠；本发明同时公开了该系统的制备方法，以及其在粘膜表面传递疫苗和药物方面的应用。
 
外文摘要：The present invention relates to a mucoadhesive carrier system, for particles, which comprises nanoscaffold having a nanofibrous layer with a thickness of from 0.1 to 1000 µm, carrying a substance in the form of particles. The mucoadhesive layer,in at least a part of its surface, overlaps the nanoscaffold. A process for its preparation and its use for delivery of the vaccines and therapeutics to mucosal surfaces is also disclosed.
NOVELTY - Solution of mucoadhesive carrier particles comprises: nanoscaffold which is nanofibrous layer with a thickness of 0.1-1000 mu , carrying a substance in particulate form; and a mucoadhesive layer, where at least a part of the mucoadhesive layer exceeds a surface of nanoscaffold.
USE - The solution of mucoadhesive carrier particles is useful for administration of vaccines and therapeutics to mucosal surfaces.
 
主权项：INDEPENDENT CLAIMS are also included for:
(1) a mucoadhesive delivery system comprising a matrix comprising at least one active ingredient, and the mucoadhesive (or adhesive means) capable of adhering the system to a mucosa; and
(2) a method for preparing a mucoadhesive carrier or system, comprising joining or contacting a nanoscaffold with a mucoadhesive layer and/or a cover layer, where an intermediate layer is inserted between the layers ( usually before joining the layers).
 
申请号：WO2015GB52833
公开/公告号：CZ201400665A3
公开/公告日：2016-04-06
申请/专利权人：UNIV PALACKEHO V OLOMOUCI (UYPA-N); GLOBALACORN LTD (GLOB-N); VU VETERINARNIHO LEKARSTVI VVI (VETE-N); VU VETERINARNIHO LEKARSTVI (VETE-N); UNIV TECHNICKA V LIBERCI (UYLI-N); UNIV PALACKEHO V OLOMOUCHI (UYPA-N)
发明/设计人：LUBASOVA, D;LUKAC, R P;MASEK, J P;RASKA, M;TURANEK, J;TURANEK, K P;KNOTIGOVA, P T;LUKAC, R;MASEK, J;MILLER, A D;KNOETIGOVA, P T
分类号：A61K9/006; A61K9/145; A61K9/19; A61K9/7007
主分类号：A61K9/00; A61K9/70
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