中文摘要： 
外文摘要：Use of vaccine is claimed, in therapy for preventing or treating disease, where the dose is a mini dose. The amount of the inactivated, typically synthetic, recombinant, killed or non-replication competent, vaccine is delivered by aerosol to the lungs on 3 or more occasions at a dose of less than the equivalent of 106 plaque-forming unit (PFU) (inactivated) or less than 0.00114. The dose is between the equivalent of 10 PFU (inactivated) and 10' PFU (inactivated). the vaccine is delivered by intra pulmonary administration as an aerosol, where the vaccine is delivered on more than 2 occasions, and the vaccine is a made in situ using a portable device and/or the vaccine is a pre-manufactured vaccine preparation.   INDEPENDENT CLAIMS are included for the following: (1) a nebulizer and vaccine in combination; (2) a composition comprising a bacterium or virus and a protective device comprising a disinfection chamber in fluid communication with a face mask, where the chamber is arranged to disinfect and/or sterilize the fluid containing the bacterium or virus in the chamber, before discharge of the fluid from the chamber, where the dose of vaccine is less than 0.03 mg and/or less than the equivalent of 10' PFU; and (3) a method for preventing or treating an infectious disease in an individual, involves administering the vaccine to the individual, where the amount is less than 3x 10-2 mu g antigen and/or the equivalent of 10' PFU.   
Preferred Method: The dose is less than 0.04 pg and/or the equivalent of 1.6x 107 PFU. The dose is administered through parenteral route without adjuvant less than 0.03 pg and with adjuvant less than 0.003 pg antigen, and through a mucosal route without adjuvant less than 1 pi antigen and/or the equivalent of 1.6x 107 PFU and with adjuvant less than 0.04 pg and/or the equivalent of 1.6x 10' PFU. The dose is less than 0.003 pg and/or less than the equivalent of 107 PFU. The dose is less than 0.001 pg and/or less than the equivalent of 5x 106 PFU. The dose is less than 0.0003 pg and/or less than the equivalent of 106 PFU. The dose is greater than 3x 10-8 and/or greater than the equivalent of 10 PFU. Preferred Product: The vaccine is administered to the lungs, where the vaccine is a pre-manufactured vaccine preparation. The vaccine is made in situ using a portable device. The vaccine is an inactivated vaccine. The vaccine is delivered as and/or comprises an aerosol. The vaccine is a viral or a bacterial vaccine. The vaccine does not comprise or is not co-administered with an adjuvant. Preferred Subject: The subject to be treated is the wearer of the protective device and/or in the environment of the wearer of the protective device. The subject to be treated has already been primed by exposure to the same, or similar, pathogen and/or has been vaccinated with a vaccine for the same or similar pathogen, where the vaccine is delivered in an initial priming dose followed by a boost, where the vaccine is delivered on 3 or more occasions to a subject. Respiratory-Gen.; Virucide; Antitubercular; Tuberculostatic; Antibacterial. No biological data given.  
Vaccine. The vaccine is administered by intrapulmonary route. No dosage details given.  The vaccine is useful in therapy for preventing or treating infectious disease in an individual or treating heterologous (related) and/or heterologous (unrelated) pathogen. The vaccine is against a respiratory infection and/or airborne infection. The vaccine is against influenza, tuberculosis, Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), measles, Ebola, Chlamydia pneumonia, respiratory syncytial virus, pneumococci or foot-and-mouth disease virus (FMDV), preferably influenza (all claimed).
申请号：GB1712098
公开/公告号：GB2564901A
申请日：2017-07-27
公开/公告日：2019-01-30
申请/专利权人：MEDI IMMUNE LTD
发明/设计人：JOHN PAUL JAMES; JAMES PRINCE LOVE; DAVID JOHN MAUDESLEY
点击下载：Use of vaccine in therapy for preventing or treating infectious disease in individual or treating heterologous (related) or heterologous (unrelated) pathogen against respiratory infection or airborne infection