中文摘要：本发明公开了一种免疫佐剂系统及其制备方法。其特征是包含一种具有免疫增强作用的重组流感病毒体（IRIVs）和免疫刺激剂；该发明阐述了将抗原被吸收和整合到IRIVs并利用脂质佐剂制备免疫佐剂系统的方法，这些脂质佐剂可以是单磷酸脂质A或葡萄糖基液体佐剂。
外文摘要：The present invention is directed to a preparation of an adjuvant system to achieve required level of humoral and cellular immune response against antigen of interest. The current invention provides an adjuvant system comprising an immunostimulating reconstituted influenza virosomes (IRIVs) and immunopotentiators. The current invention illustrates that an antigen is adsorbed or incorporated into IRIVs and further formulated with lipophilic adjuvant such as MPL or glucopyranosyl lipid adjuvant (synthetic analogue of MPL).
主权项：(1) a method for preparing immunogenic composition, which involves formulating virosome, adsorbing or incorporating antigen to prepare modified virosome having antigen, and adding adjuvant to modified virosome having adsorbed antigen;
(2) a method for preparing adjuvant system, which involves formulating a modified virosome with lipophilic antigen or hydrophilic antigen, and adding adjuvant into the modified virosome having antigen;
(3) a pharmaceutical composition comprises immunogenic composition with pharmaceutically acceptable carrier or excipient for inducing an immune response against antigen; and 
(4) a method for stimulating immune response of patient involves administering a suitable dosage of immunogenic composition to the patient.
申请号：TW201620926A
公开/公告号：TW201620926A
申请日：2015-09-01
公开/公告日：2016-06-16
申请/专利权人：CADILA HEALTHCARE LTD (CDLA-C)
发明/设计人：GUPTA, G; FICHERA, E; GLUECK, R
分类号： A61K39/008; A61K39/145; A61K39/39; A61K2039/5258; A61K2039/55555; A61K2039/55572
主分类号：A61K39/145；C07K14/11
法律状态：公开发明
点击下载：一种由具有免疫增强作用的重组流感病毒体和免疫增强剂组成的可以刺激免疫反应的化合物及其包含该化合物的疫苗