中文摘要：滥用抗生素引起的耐药性可能给人类带来灾难。因此，需要开发新的纳米抗生素来对抗细菌感染。本研究将石墨烯纳米薄片/Cr2O3纳米复合材料(GNPs/Cr2O3) 作为一种潜在的纳米药物。通过研究该复合材料对绿脓杆菌和金黄色葡萄球菌的抗菌特性发现，优化GNPs含量后，GCr2O3 -II对金黄色葡萄球菌(革兰氏阳性菌)的抑菌率为84.25%，对绿脓杆菌(革兰氏阴性菌)的抑菌率为80.76%，这可以归因于GNPs的尖锐边缘和Cr2O3纳米片诱导的氧化应激协同破坏了细菌膜结构。研究结果表明GNPs/Cr2O3纳米复合材料可以作为一种新型的纳米抗生素用于控制病原菌。
外文摘要：Drug resistance resulting due to the abuse of antibiotics can possibly be fatal for human beings. It, therefore, is required to develop novel nanoantibiotics to fight with the bacterial infections. In this work, we report graphene nanoplatelets/Cr2O3 nanocomposites (GNPs/Cr2O3) as a potential nanomedicine. Antibacterial characteristics of GNPs/Cr2O3 nanocomposites have been investigated against Pseudomonas aeruginosa and Staphylococcus aureus. GCr(2)O(3)-II with the optimized GNPs' content shows excellent antibacterial performance with 84.25% growth inhibition of S. aureus (Gram-positive bacteria) and 80.76% growth inhibition of-P. aeruginosa (Gram-negative bacteria). This can be attributed to the synergistic contribution of Cr2O3 nanoflakes and GNPs/Cr2O3 nano-composites, towards bacterial membrane disruption, that may be caused by the sharp edges of GNPs and induction of the oxidative stress by Cr2O3 nanoflakes. Therefore, this study suggests that GNPs/Cr2O3 nanocomposites can be employed as an innovative nanoantibiotics for pathogen control.
外文关键词：Pathogen control; Nanoantibiotics; Graphene/Cr2O3Nanocomposites
作者：Talat, I；Arshad, A；Mansoor, Q
作者单位：Int Islamic Univ；Inst Biomed & Genet Engn IBGE
期刊名称：CERAMICS INTERNATIONAL
期刊影响因子：3.83
出版年份：2021
出版刊次：47
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